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Cerebellar-Dependent Learning in Larval Zebrafish

Aizenberg, Mark and Schuman, Erin M. (2011) Cerebellar-Dependent Learning in Larval Zebrafish. Journal of Neuroscience, 31 (24). pp. 8708-8712. ISSN 0270-6474. PMCID PMC6622926. https://resolver.caltech.edu/CaltechAUTHORS:20110705-132153102

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Abstract

Understanding how neuronal network activity contributes to memory formation is challenged by the complexity of most brain circuits and the restricted ability to monitor the activity of neuronal populations in vivo. The developing zebrafish (Danio rerio) is an animal model that circumvents these problems, because zebrafish larvae possess a rich behavioral repertoire and an accessible brain. Here, we developed a classical conditioning paradigm in which 6- to 8-d-old larvae develop an enhanced motor response to a visual stimulus (conditioned stimulus, CS) when it is paired with touch (unconditioned stimulus, US). Using in vivo calcium imaging we demonstrate that CS and US activate different subsets of neurons in the cerebellum; their activity, modulated by learning two-photon laser ablation, revealed that the cerebellum is involved in acquisition and extinction, but not the retention, of this memory.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.6565-10.2011DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622926PubMed CentralArticle
Additional Information:© 2011 the authors. Received Dec. 16, 2010; revised March 25, 2011; accepted April 15, 2011. Funding from the Gordon and Betty Moore Foundation supported this work. We gratefully acknowledge Ueli Rutishauser, Flora Hinz, and Gilles Laurent for comments on the manuscript. We thank Sally Kim for help with the imaging set-up and all Schuman group members for helpful discussions and criticism. Author contributions: M.A. and E.M.S. designed research; M.A. performed research; M.A. analyzed data; M.A. and E.M.S. wrote the paper.
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Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:24
PubMed Central ID:PMC6622926
Record Number:CaltechAUTHORS:20110705-132153102
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110705-132153102
Official Citation:Mark Aizenberg and Erin M. Schuman Cerebellar-Dependent Learning in Larval Zebrafish The Journal of Neuroscience, 15 June 2011, 31(24):8708-8712; doi:10.1523/JNEUROSCI.6565-10.2011
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24298
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Jul 2011 20:41
Last Modified:03 Oct 2019 02:55

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