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Formation and Stability of Synaptic Receptor Domains

Haselwandter, Christoph A. and Calamai, Martino and Kardar, Mehran and Triller, Antoine and da Silveira, Rava Azeredo (2011) Formation and Stability of Synaptic Receptor Domains. Physical Review Letters, 106 (23). Art. No. 238104. ISSN 0031-9007. https://resolver.caltech.edu/CaltechAUTHORS:20110705-142915363

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Abstract

Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Combining experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model. We show that interactions between only receptors and scaffolds, together with the rapid diffusion of receptors on the cell membrane, are sufficient for the formation and stable characteristic size of synaptic receptor domains. Our work reconciles long-term stability of synaptic receptor domains with rapid turnover and diffusion of individual receptors, and suggests novel mechanisms for a form of short-term, postsynaptic plasticity.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1103/PhysRevLett.106.238104DOIUNSPECIFIED
http://link.aps.org/doi/10.1103/PhysRevLett.106.238104PublisherUNSPECIFIED
Additional Information:© 2011 American Physical Society. Received 17 December 2010; published 8 June 2011. R. A. d. S. is grateful to Philippe Ascher and Jean-Pierre Changeux for illuminating discussions. This work was supported by the Austrian Science Fund (C. A. H.), the Pierre-Gilles de Gennes Foundation and a FEBS grant (M. C.), the NSF through Grant No. DMR-08-03315 and the Ecole Normale Supéieure (M. K.), the Inserm UR 789 (A. T.), and the CNRS through UMR 8550 (R. A. d. S.).
Funders:
Funding AgencyGrant Number
Austrian Science FundUNSPECIFIED
Pierre-Gilles de Gennes FoundationUNSPECIFIED
FEBS grantUNSPECIFIED
NSFDMR-08-03315
Ecole Normale SupéieureUNSPECIFIED
Inserm UR 789UNSPECIFIED
CNRS through UMR 8550UNSPECIFIED
Issue or Number:23
Classification Code:PACS: 87.16.-b, 82.40.-g, 87.19.lp, 87.19.lw
Record Number:CaltechAUTHORS:20110705-142915363
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110705-142915363
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24302
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:06 Jul 2011 14:31
Last Modified:03 Oct 2019 02:55

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