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High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications

Vermesh, Udi and Vermesh, Ophir and Wang, Jun and Kwong, Gabriel A. and Ma, Chao and Hwang, Kiwook and Heath, James R. (2011) High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications. Angewandte Chemie International Edition, 50 (32). pp. 7378-7380. ISSN 1433-7851. PMCID PMC3651859. https://resolver.caltech.edu/CaltechAUTHORS:20110706-095329536

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Abstract

Surface chemistry meets tissue engineering: A novel surface-patterning approach for creating arrays of DNA squares is combined with a unique method for DNA-encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/ 10.1002/anie.201102249DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201102249/abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651859/PubMed CentralArticle
ORCID:
AuthorORCID
Heath, James R.0000-0001-5356-4385
Additional Information:© 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: March 31, 2011. Published online: June 29, 2011. This work was funded by the National Cancer Institute Grant No. 5U54 CA119347 (JRH PI) and by generous support from the Ivy Foundation and the Grand Duchy of Luxembourg, via a subcontract from the Institute for Systems Biology. We thank Integrated Sensing Systems, Inc. for help with silicon hard mold fabrication and M. Di Franco for technical assistance.
Funders:
Funding AgencyGrant Number
National Cancer Institute5U54 CA119347
Ivy FoundationUNSPECIFIED
Grand Duchy of LuxembourgUNSPECIFIED
Subject Keywords:cell assembly; flow-patterning; microarrays; microfluidics; tissue engineering
Issue or Number:32
PubMed Central ID:PMC3651859
Record Number:CaltechAUTHORS:20110706-095329536
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110706-095329536
Official Citation:Vermesh, U., Vermesh, O., Wang, J., Kwong, G. A., Ma, C., Hwang, K. and Heath, J. R. (2011), High-Density, Multiplexed Patterning of Cells at Single-Cell Resolution for Tissue Engineering and Other Applications. Angewandte Chemie International Edition, 50: 7378–7380. doi: 10.1002/anie.201102249
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24313
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:05 Aug 2011 18:50
Last Modified:03 Oct 2019 02:55

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