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Glycolytic Oscillations and Limits on Robust Efficiency

Chandra, Fiona A. and Buzi, Gentian and Doyle, John C. (2011) Glycolytic Oscillations and Limits on Robust Efficiency. Science, 333 (6039). pp. 187-192. ISSN 0036-8075.

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Both engineering and evolution are constrained by trade-offs between efficiency and robustness, but theory that formalizes this fact is limited. For a simple two-state model of glycolysis, we explicitly derive analytic equations for hard trade-offs between robustness and efficiency with oscillations as an inevitable side effect. The model describes how the trade-offs arise from individual parameters, including the interplay of feedback control with autocatalysis of network products necessary to power and catalyze intermediate reactions. We then use control theory to prove that the essential features of these hard trade-off “laws” are universal and fundamental, in that they depend minimally on the details of this system and generalize to the robust efficiency of any autocatalytic network. The theory also suggests worst-case conditions that are consistent with initial experiments.

Item Type:Article
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URLURL TypeDescription
Doyle, John C.0000-0002-1828-2486
Additional Information:© 2011 American Association for the Advancement of Science. Received 22 November 2010; accepted 2 May 2011. The authors thank H. El-Samad and J. Stewart-Ornstein at the University of California, San Francisco, for their laboratory space and assistance; N. Pierce (Ray Deshaies’ lab) for the green fluorescent protein library; O. Venturelli (Richard Murray’s lab) for her help; and M. Csete for helpful feedback. Microscopy was performed at the Nikon Imaging Center at UCSF. Experimental data are available in SOM. This work is supported by the NIH (award R01GM078992A) and Institute of Collaborative Biotechnologies from the U.S. Army Research Office (subaward KK4102, prime award DAAD19-03-D-0004).
Funding AgencyGrant Number
U. S. Army Research Office Insititute of Collaborative Biotechnologies subawardKK4102
U. S. Army Research Office Insititute of Collaborative Biotechnologies prime awardDAAD19-03-D-0004
Issue or Number:6039
Record Number:CaltechAUTHORS:20110712-150344607
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Official Citation:Glycolytic Oscillations and Limits on Robust Efficiency Fiona A. Chandra, Gentian Buzi, and John C. Doyle Science 8 July 2011: 187-192. [DOI:10.1126/science.1200705]
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24390
Deposited By: Ruth Sustaita
Deposited On:12 Jul 2011 22:26
Last Modified:26 Nov 2019 11:15

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