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The role of IkB kinase complex in the neurobiology of Huntington's disease

Khoshnan, Ali and Patterson, Paul H. (2011) The role of IkB kinase complex in the neurobiology of Huntington's disease. Neurobiology of Disease, 43 (2). pp. 305-311. ISSN 0969-9961. PMCID PMC3124142. http://resolver.caltech.edu/CaltechAUTHORS:20110713-071554645

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Abstract

The IκB kinase β (IKKβ) is a prominent regulator of neuroinflammation, which is implicated in the pathogenesis of Huntington's disease (HD). Inflammatory mediators accumulate in the serum and CNS of premanifest and manifest HD patients, and cytokine levels correlate with disease progression. IKKβ may also directly regulate the neurotoxicity of huntingtin (Htt). Activation of IKKβ by DNA damage triggers caspase-dependent cleavage of WT and mutant Htt and enhances the accumulation of oligomeric fragments. Moreover, the N-terminal fragments of mutant Htt (HDx1) directly bind to and activate IKKβ. Thus, the IKKβ-dependent cleavage of full-length mutant Htt and the buildup of HDx1 could form a deleterious feed-forward loop. Elevated IKKβ activity is present throughout the CNS in a symptomatic mouse model of HD expressing HDx1, whereas in asymptomatic mice with full-length mutant Htt, it is confined to the striatum. IKKβ could also influence the phosphorylation of Htt at Ser13 and Ser16, which is linked to HD pathology. IKKβ inhibitors ameliorate the toxicity of mutant Htt in striatal neurons and prevent DNA damage-induced Htt cleavage. Inhibition of IKKβ in the CNS also reduces neuroinflammation and imparts neuroprotection in a chemical model of HD. These findings support an active role for IKKβ in HD pathogenesis and represent an example of how gene–environment (exemplified by DNA damage and inflammation) interactions can influence Htt neurotoxicity. We will summarize these findings and describe the therapeutic potentials of IKKβ for HD.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.nbd.2011.04.015 DOIArticle
http://www.sciencedirect.com/science/article/pii/S096999611100132XPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124142/PubMed CentralArticle
Additional Information:© 2011 Elsevier Inc. Received 16 March 2011; revised 13 April 2011; accepted 21 April 2011. Available online 5 May 2011.
Subject Keywords:Huntington's disease; IKKβ; Neuroinflammation; Htt cleavage; DNA damage
PubMed Central ID:PMC3124142
Record Number:CaltechAUTHORS:20110713-071554645
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110713-071554645
Official Citation:Ali Khoshnan, Paul H. Patterson, The role of I[kappa]B kinase complex in the neurobiology of Huntington's disease, Neurobiology of Disease, Volume 43, Issue 2, August 2011, Pages 305-311, ISSN 0969-9961, DOI: 10.1016/j.nbd.2011.04.015. (http://www.sciencedirect.com/science/article/pii/S096999611100132X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24395
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Jul 2011 16:39
Last Modified:23 Aug 2016 10:03

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