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Flexible Microfabricated Parylene Multielectrode Arrays for Retinal Stimulation and Spinal Cord Field Modulation

Rodger, Damien C. and Li, Wen and Fong, Andy J. and Ameri, Hossein and Meng, Ellis and Burdick, Joel W. and Roy, Roland R. and Edgerton, V. Reggie and Weiland, James D. and Humayun, Mark S. and Tai, Yu-Chong (2006) Flexible Microfabricated Parylene Multielectrode Arrays for Retinal Stimulation and Spinal Cord Field Modulation. In: 2006 International Conference on Microtechnologies in Medicine and Biology. IEEE , Piscataway, NJ, pp. 31-34. ISBN 978-1-4244-0337-0. https://resolver.caltech.edu/CaltechAUTHORS:20110720-113158743

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Abstract

The first flexible parylene-based multielectrode arrays (MEAs) designed for functional electrical stimulation (FES) in retinal prostheses, and the extension of this technology toward enabling reflex-arc neuromodulation in cases of spinal cord damage or transection, are presented. A single metal layer 16 × 16 retinal electrode array of 125 μm-diameter thin-film Ti/Pt electrodes and lines of 12 μm-pitch has been fabricated as a demonstration of this technology. To allow for even higher density arrays, a novel dual-layer process has also been implemented that enables leads to pass under overlying electrodes without making electrical contact to them. A biomimetic parylene-based electrode array consisting of 1024 electrodes of highly variable spacing, 60 of which have been connected in this manner, has been fabricated according to this paradigm. A parylene-parylene annealing process has also been developed to increase device longevity under accelerated-lifetime saline soak conditions. Surgical tests of novel anatomically-conformal geometries that enable such parylene-based electrode systems to interact with their neuronal targets of interest while causing minimal mechanical damage to tissues or to the implants are also presented. The use of these flexible electrode arrays in spinal cord stimulation experiments in animal models has proven their efficacy in stimulating neurons.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/MMB.2006.251482 DOIArticle
http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4281300&tag=1PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2006 IEEE. Issue Date: 9-12 May 2006. Date of Current Version: 30 July 2007. This work was supported in part by the Engineering Research Centers Program of the National Science Foundation under NSF Award Number EEC-0310723, and by a fellowship from the Whitaker Foundation (D.R.). The authors especially wish to thank Mr. Trevor Roper and other members of the Caltech Micromachining Laboratory for their valuable assistance.
Funders:
Funding AgencyGrant Number
NSFEEC-0310723
Whitaker FoundationUNSPECIFIED
Subject Keywords:BioMEMS; Dual-layer; Electrode array; Neural prosthesis; Parylene; Retinal prosthesis
Record Number:CaltechAUTHORS:20110720-113158743
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110720-113158743
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24484
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:20 Jul 2011 20:13
Last Modified:03 Oct 2019 02:56

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