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Differentiable contributions of human amygdalar subregions in the computations underlying reward and avoidance learning

Prévost, Charlotte and McCabe, Jonathan A. and Jessup, Ryan K. and Bossaerts, Peter and O’Doherty, John P. (2011) Differentiable contributions of human amygdalar subregions in the computations underlying reward and avoidance learning. European Journal of Neuroscience, 34 (1). pp. 134-145. ISSN 0953-816X. https://resolver.caltech.edu/CaltechAUTHORS:20110722-140235494

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Abstract

To understand how the human amygdala contributes to associative learning, it is necessary to differentiate the contributions of its subregions. However, major limitations in the techniques used for the acquisition and analysis of functional magnetic resonance imaging (fMRI) data have hitherto precluded segregation of function with the amygdala in humans. Here, we used high-resolution fMRI in combination with a region-of-interest-based normalization method to differentiate functionally the contributions of distinct subregions within the human amygdala during two different types of instrumental conditioning: reward and avoidance learning. Through the application of a computational-model-based analysis, we found evidence for a dissociation between the contributions of the basolateral and centromedial complexes in the representation of specific computational signals during learning, with the basolateral complex contributing more to reward learning, and the centromedial complex more to avoidance learning. These results provide unique insights into the computations being implemented within fine-grained amygdala circuits in the human brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1460-9568.2011.07686.xDOIUNSPECIFIED
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2011.07686.x/abstractPublisherUNSPECIFIED
ORCID:
AuthorORCID
Bossaerts, Peter0000-0003-2308-2603
Additional Information:© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd. Received 10 March 2011, accepted 21 March 2011. Article first published online: 3 May 2011. We thank Christian Kerskens and Mimi Liljeholm for helpful discussions. This work was funded by Science Foundation Ireland grant 08/IN.1/B1844 to J.O.D.
Funders:
Funding AgencyGrant Number
Science Foundation Ireland08/IN.1/B1844
Subject Keywords:basolateral complex; centromedial complex; high-resolution fMRI; instrumental learning
Issue or Number:1
Record Number:CaltechAUTHORS:20110722-140235494
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110722-140235494
Official Citation:Prévost, C., McCabe, J. A., Jessup, R. K., Bossaerts, P. and O’Doherty, J. P. (2011), Differentiable contributions of human amygdalar subregions in the computations underlying reward and avoidance learning. European Journal of Neuroscience, 34: 134–145. doi: 10.1111/j.1460-9568.2011.07686.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24511
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Sep 2011 18:27
Last Modified:03 Oct 2019 02:57

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