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Parylene Neurocages for Electrical Stimulation on Silicon and Glass Substrates

Tooker, Angela and Erickson, Jon and Chow, Gary and Tai, Yu-Chong and Pine, Jerry (2006) Parylene Neurocages for Electrical Stimulation on Silicon and Glass Substrates. In: 2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 4322-4325. ISBN 1-4244-0032-5. https://resolver.caltech.edu/CaltechAUTHORS:20110726-110245674

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Abstract

We present a refined method and design for building parylene neurocages for in vitro studies of live neural networks. Parylene neurocages are biocompatible and very robust, making them ideally suited for studying the synaptic connections between individual neurons to gain insight into learning and memory. The neurocage fabrication process incorporates electrodes into the neurocages to allow for stimulation and recording of action potentials. These neurocages can be fabricated on either silicon or glass substrates. The resulting neurocages have a long term cell survival rate of ~50%, and have proven to be 99% effective in trapping neurons. Preliminary results demonstrate that current pulses passing through the electrode can stimulate action potentials in the neurons trapped in neurocages.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/IEMBS.2006.260472 DOIArticle
http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=4462757PublisherArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2006 IEEE. Manuscript received April 3, 2006. This work was supported by the NIH under Award Number R01 NSO44134. We would like to thank Mr. Trevor Roper for assistance with fabrication and testing and Mr. Pat Koen for assistance with obtaining the SEMs.
Funders:
Funding AgencyGrant Number
NIHR01 NSO44134
Record Number:CaltechAUTHORS:20110726-110245674
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20110726-110245674
Official Citation:Tooker, A.; Erickson, J.; Chow, G.; Yu-Chong Tai; Pine, J.; , "Parylene Neurocages for Electrical Stimulation on Silicon and Glass Substrates," Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE , vol., no., pp.4322-4325, Aug. 30 2006-Sept. 3 2006 doi: 10.1109/IEMBS.2006.260472 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=4462757&isnumber=4461641
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24546
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Jul 2011 23:31
Last Modified:03 Oct 2019 02:57

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