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Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents

Somerville, Leah H. and Hare, Todd and Casey, B. J. (2011) Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents. Journal of Cognitive Neuroscience, 23 (9). pp. 2123-2134. ISSN 0898-929X. http://resolver.caltech.edu/CaltechAUTHORS:20110803-103931835

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Abstract

Adolescent risk-taking is a public health issue that increases the odds of poor lifetime outcomes. One factor thought to influence adolescents' propensity for risk-taking is an enhanced sensitivity to appetitive cues, relative to an immature capacity to exert sufficient cognitive control. We tested this hypothesis by characterizing interactions among ventral striatal, dorsal striatal, and prefrontal cortical regions with varying appetitive load using fMRI scanning. Child, teen, and adult participants performed a go/no-go task with appetitive (happy faces) and neutral cues (calm faces). Impulse control to neutral cues showed linear improvement with age, whereas teens showed a nonlinear reduction in impulse control to appetitive cues. This performance decrement in teens was paralleled by enhanced activity in the ventral striatum. Prefrontal cortical recruitment correlated with overall accuracy and showed a linear response with age for no-go versus go trials. Connectivity analyses identified a ventral frontostriatal circuit including the inferior frontal gyrus and dorsal striatum during no-go versus go trials. Examining recruitment developmentally showed that teens had greater between-subject ventral-dorsal striatal coactivation relative to children and adults for happy no-go versus go trials. These findings implicate exaggerated ventral striatal representation of appetitive cues in adolescents relative to an intermediary cognitive control response. Connectivity and coactivity data suggest these systems communicate at the level of the dorsal striatum differentially across development. Biased responding in this system is one possible mechanism underlying heightened risk-taking during adolescence.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1162/jocn.2010.21572DOIUNSPECIFIED
http://www.mitpressjournals.org/doi/abs/10.1162/jocn.2010.21572PublisherUNSPECIFIED
Additional Information:© 2011 Massachusetts Institute of Technology. Posted Online July 6, 2011. The authors gratefully acknowledge the assistance of Doug Ballon, Adriana Galvan, Gary Glover, Victoria Libby, Erika Ruberry, Theresa Teslovich, Nim Tottenham, Henning Voss, and the resources and the staff at the Biomedical Imaging Core Facility of the Citigroup Biomedical Imaging Center at Weill Cornell Medical College. This work was supported by the National Institute of Mental Health grant nos. P50MH062196 and P50MH079513, the National Institute of Drug Abuse grant nos. R01DA018879 and T32DA007274, and the National Institute ofMental Health Fellowship grant no. F31MH073265.
Funders:
Funding AgencyGrant Number
National Institute of Mental HealthP50MH062196
National Institute of Mental HealthP50MH079513
National Institute of Drug AbuseR01DA018879
National Institute of Drug AbuseT32DA007274
National Institute of Mental Health FellowshipF31MH073265
Record Number:CaltechAUTHORS:20110803-103931835
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20110803-103931835
Official Citation:Frontostriatal Maturation Predicts Cognitive Control Failure to Appetitive Cues in Adolescents Leah H. Somerville, Todd Hare and B. J. Casey Journal of Cognitive Neuroscience 2011 23:9, 2123-2134
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24650
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:03 Aug 2011 20:13
Last Modified:26 Dec 2012 13:26

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