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Causal isolation robustness analysis: the combinatorial strategy of circadian clock research

Knuuttila, Tarja and Loettgers, Andrea (2011) Causal isolation robustness analysis: the combinatorial strategy of circadian clock research. Biology and Philosophy, 26 (5). pp. 773-791. ISSN 0169-3867.

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This paper distinguishes between causal isolation robustness analysis and independent determination robustness analysis and suggests that the triangulation of the results of different epistemic means or activities serves different functions in them. Circadian clock research is presented as a case of causal isolation robustness analysis: in this field researchers made use of the notion of robustness to isolate the assumed mechanism behind the circadian rhythm. However, in contrast to the earlier philosophical case studies on causal isolation robustness analysis (Weisberg and Reisman in Philos Sci 75:106–131, 2008; Kuorikoski et al. in Br J Philos Sci 61:541–567, 2010), robustness analysis in the circadian clock research did not remain in the level of mathematical modeling, but it combined it with experimentation on model organisms and a new type of model, a synthetic model.

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Additional Information:© 2011 Springer Science+Business Media B.V. Published online: 22 June 2011. The authors would like to thank the Academy of Finland and the Alfred P. Sloan Foundation for the support of this research.
Funding AgencyGrant Number
Academy of FinlandUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Subject Keywords:Modeling; Robustness analysis; Causal isolation; Synthetic biology; Circadian clock
Issue or Number:5
Record Number:CaltechAUTHORS:20110805-095227169
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24705
Deposited By: Jason Perez
Deposited On:05 Aug 2011 20:15
Last Modified:03 Oct 2019 02:59

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