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Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice

Hsu, Cynthia T. and Dollár, Piotr and Chang, Daniel and Steele, Andrew D. (2010) Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice. PLoS ONE, 5 (11). Art. No. e15429. ISSN 1932-6203. PMCID PMC2972719.

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Anticipation of resource availability is a vital skill yet it is poorly understood in terms of neuronal circuitry. Rodents display robust anticipatory activity in the several hours preceding timed daily access to food when access is limited to a short temporal duration. We tested whether this anticipatory behavior could be generalized to timed daily social interaction by examining if singly housed male mice could anticipate either a daily novel female or a familiar female. We observed that anticipatory activity was moderate under both conditions, although both a novel female partner and sexual experience are moderate contributing factors to increasing anticipatory activity. In contrast, restricted access to running wheels did not produce any anticipatory activity, suggesting that an increase in activity during the scheduled access time was not sufficient to induce anticipation. To tease apart social versus sexual interaction, we tested the effect of exposing singly housed female mice to a familiar companion female mouse daily. The female mice did not show anticipatory activity for restricted female access, despite a large amount of social interaction, suggesting that daily timed social interaction between mice of the same gender is insufficient to induce anticipatory activity. Our study demonstrates that male mice will show anticipatory activity, albeit inconsistently, for a daily timed sexual encounter.

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Additional Information:© 2010 Hsu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received July 30, 2010; Accepted September 20, 2010; Published November 3, 2010. Editor: Shin Yamazaki, Vanderbilt University, United States of America. Funding: This work was funded by the Broad Fellows in Brain Circuitry Program at Caltech, the Ellison Medical Foundation new scholar award, and the Klarman Family Foundation Grants Program in Eating Disorders Research to ADS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the Caltech animal husbandry staff, Keith Gunapala for helpful advice and assistance with experiments, Christopher Levin and Alex Paul for video annotations, Ian Webb for comments on the manuscript, and Christof Koch, Pietro Perona, and David Anderson for support. Author Contributions: Conceived and designed the experiments: CTH ADS. Performed the experiments: CTH DC PD ADS. Analyzed the data: CTH DC PD ADS. Contributed reagents/materials/analysis tools: PD. Wrote the paper: CTH ADS.
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Caltech Brain Circuitry ProgramUNSPECIFIED
Ellison Medical FoundationUNSPECIFIED
Klarman Family FoundationUNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC2972719
Record Number:CaltechAUTHORS:20110812-091953543
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Official Citation:Hsu CT, Dolla´r P, Chang D, Steele AD (2010) Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice. PLoS ONE 5(11): e15429. doi:10.1371/journal.pone.0015429
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:24818
Deposited By: Tony Diaz
Deposited On:19 Sep 2011 20:34
Last Modified:12 Feb 2020 20:09

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