Lassila, Kirsten S. and Datta, Deepshikha and Mayo, Stephen L. (2002) Evaluation of the energetic contribution of an ionic network to beta-sheet stability. Protein Science, 11 (3). pp. 688-690. ISSN 0961-8368. PMCID PMC2373463. doi:10.1110/ps.23502. https://resolver.caltech.edu/CaltechAUTHORS:20110928-153816383
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Abstract
We have evaluated the interaction energy of a three-residue ionic network constructed on the β-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by ~0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol).
| Item Type: | Article | |||||||||
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| Contact Email Address: | steve@mayo.caltech.edu | |||||||||
| Additional Information: | © 2002 The Protein Society. Received June 19, 2001; Accepted November 30, 2001. Article first published online: 13 Apr. 2009. | |||||||||
| Subject Keywords: | Nerve Tissue Proteins; Amino Acids; Thermodynamics; Ions; Protein Structure: Secondary; Static Electricity; Kinetics; Models: Molecular; Mutation; Protein Binding; Protein Structure: Tertiary; β-Sheet; protein stability; protein design; electrostatics; side chain interactions | |||||||||
| Issue or Number: | 3 | |||||||||
| PubMed Central ID: | PMC2373463 | |||||||||
| DOI: | 10.1110/ps.23502 | |||||||||
| Record Number: | CaltechAUTHORS:20110928-153816383 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20110928-153816383 | |||||||||
| Official Citation: | Lassila, K. S., Datta, D. and Mayo, S. L. (2002), Evaluation of the energetic contribution of an ionic network to beta-sheet stability. Protein Science, 11: 688–690. doi: 10.1110/ps.23502 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 25478 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 29 Sep 2011 16:24 | |||||||||
| Last Modified: | 09 Nov 2021 16:33 |
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