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Ancestral Network Module Regulating prdm1 Expression in the Lamprey Neural Plate Border

Nikitina, Natalya and Tong, Leslie and Bronner, Marianne E. (2011) Ancestral Network Module Regulating prdm1 Expression in the Lamprey Neural Plate Border. Developmental Dynamics, 240 (10). pp. 2265-2271. ISSN 1058-8388. PMCID PMC3277493. https://resolver.caltech.edu/CaltechAUTHORS:20111014-122805711

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Abstract

prdm1 is an important transcriptional regulator that plays diverse roles during development of a wide variety of vertebrate and invertebrate species. prdm1 is required for neural crest specification in zebrafish, but not in mouse embryos. The role of this gene in neural crest formation in other species has not been examined, and its regulation during embryonic development is poorly understood. Here, we investigate the expression pattern, function, and the upstream regulatory inputs into prdm1 during lamprey neural crest development. prdm1 is strongly expressed in the lamprey neural plate border, suggesting a conserved ancestral role of this gene in the neural crest formation. We found that lamprey neural plate border expression of prdm1 is activated by Ap-2 and Msx, but is independent of Pax3/7 and Zic.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/dvdy.22720DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22720/abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277493/PubMed CentralArticle
ORCID:
AuthorORCID
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2011 Wiley-Liss, Inc. Issue published online: 19 September 2011; Article first published online: 25 August 2011; Manuscript Accepted: 1 August 2011. This work was funded by NIH grant DE017911 to M.E.B.
Funders:
Funding AgencyGrant Number
NIHDE017911
Subject Keywords:prdm1; lamprey; neural crest; Blimp-1; MsxA; Ap-2; Pax7
Issue or Number:10
PubMed Central ID:PMC3277493
Record Number:CaltechAUTHORS:20111014-122805711
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111014-122805711
Official Citation:Nikitina, N., Tong, L. and Bronner, M. E. (2011), Ancestral network module regulating prdm1 expression in the lamprey neural plate border. Developmental Dynamics, 240: 2265–2271. doi: 10.1002/dvdy.22720
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27233
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:14 Oct 2011 21:29
Last Modified:03 Oct 2019 03:21

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