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Size, subunit composition, and secondary structure of the Friend virus genome

Dube, Shyam and Kung, Hsing-Jien and Bender, Welcome and Davidson, Norman and Ostertag, Wolfram (1976) Size, subunit composition, and secondary structure of the Friend virus genome. Journal of Virology, 20 (1). pp. 264-272. ISSN 0022-538X.

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Electron microscope and gel electrophoresis studies show that the high-molecular-weight (50 to 70S) RNA extract from Friend virus (FV) is a dimer with the same basic structure previously observed for the RNAs from RD-114 virus, baboon virus, and woolly monkey virus. This observation greatly strengthens the inference that the dimer structure is a general characteristic of the RNAs of all mammalian type C viruses. The FV dimer is slightly less stable than the RNA dimer of woolly monkey virus, which is, in turn, much less stable than those of RD-114 and baboon virus. There are three FV monomer components, small (S), medium (M), and large (L), with molecular lengths of 6.7 +/- 0.6, 7.7 +/- 0.6, and 9.5 +/- 0.6 kilobases, respectively. There are approximately equal amounts of the S and M components and much less of the L component. Most of the dimers are homodimers (SS, MM, and LL). The frequency of heterodimers (SM, SL, ML) is much less than expected for a random assortment model.

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Additional Information:Copyright © 1976 American Society for Microbiology. Received for publication 5 May 1976 S.D. has been supported as a Sherman Fairchild Distinguished Scholar at the California Institute of Technology. W.B. has been the recipient of a National Science Foundation fellowship and of a training grant from the National Institutes of Health. This research has been supported by a contract, NO-1-CP-43306 within the Virus-Cancer Program of the National Cancer Institute. Contribution no. 5302 from the Department of Chemistry, California Institute of Technology, Pasadena, CA 91125.
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Deposited On:24 Apr 2006
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