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Bio-organometallic Approaches to Nitrogen Fixation Chemistry

Peters, Jonas C. and Mehn, Mark P. (2006) Bio-organometallic Approaches to Nitrogen Fixation Chemistry. In: Activation of small molecules: organometallic and bioinorganic perspectives. Wiley-VCH , pp. 81-119. ISBN 9783527313129.

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Biological and industrial nitrogen fixation are the processes by which one of the most inert molecules, N_2, is transformed into a bioavailable nitrogen source (e.g. NH_3) that can be incorporated into all nitrogen-containing biomolecules [1]. As such, nitrogen fixation is essential to sustaining life on this planet, and has attracted intense scrutiny among biological and chemical communities for decades [2-4]. The mechanism by which nitrogenase enzymes promote the biological reduction of nitrogen under ambient conditions remains an unsolved and fascinating problem [4-6]. Nature's solution to fixing nitrogen stands in sharp contrast to that which humanity has adopted, i.e. the Haber-Bosch process for ammonia synthesis that is carried out at approximately 200 atm and 500°C. This Herculean feat of chemical engineering provides, in net, about 50% of the nitrogen atoms that wind up in all human beings on this planet [7]. From a chemists perspective, however, this remains a brute force and high-energy solution to the nitrogen fixation problem, especially given the knowledge that nature can fix N_2 under ambient conditions.

Item Type:Book Section
Peters, Jonas C.0000-0002-6610-4414
Additional Information:© 2006 Wiley-VCH. We are grateful to the NIH for their generous support: GM-070757 (J.C.P.), post-doctoral fellowship GM-072291 (M.P.M.). We also express thanks to Dr. Johannes Kaestner and Professor Peter Blöchl for providing the coordinate file to generate Fig. 3.14.
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Record Number:CaltechAUTHORS:20111018-082532542
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27268
Deposited By: Tony Diaz
Deposited On:18 Oct 2011 17:31
Last Modified:26 Nov 2019 11:15

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