Potter, Steven M. and Wagenaar, Daniel A. and Madhavan, Radhika and DeMarse, Thomas B. (2003) Long-Term Bidirectional Neuron Interfaces for Robotic Control, and In Vitro Learning Studies. In: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 3690-3693. ISBN 0-7803-7789-3. https://resolver.caltech.edu/CaltechAUTHORS:20111020-154335843
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Abstract
There are two fundamentally different goals for neural interfacing. On the biology side, to interface living neurons to external electronics allows the observation and manipulation of neural circuits to elucidate their fundamental mechanisms. On the engineering side, neural interfaces in animals, people, or in cell culture have the potential to restore missing functionality, or someday, to enhance existing functionality. At the Laboratory for NeuroEngineering at Georgia Tech, we are developing new technologies to help make both goals attainable. We culture dissociated mammalian neurons on multi-electrode arrays, and use them as the brain of a 'Hybrot', or hybrid neural-robotic system. Distributed neural activity patterns are used to control mobile robots. We have created the hardware and software necessary to feed the robots' sensory inputs back to the cultures in real time, as electrical stimuli. By embodying cultured networks, we study learning and memory at the cellular and network level, using 2-photon laser-scanning microscopy to image plasticity while it happens. We have observed a very rich dynamical landscape of activity patterns in networks of only a few thousand cells. We can alter this landscape via electrical stimuli, and use the hybrot system to study the emergent properties of networks in vitro.
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| Additional Information: | © 2003 IEEE. Issue Date: 17-21 Sept. 2003; Date of Current Version: 05 April 2004. Much of the work was carried out with help and support from Prof. Jerome Pine and Prof. Scott E. Fraser at Caltech. | |||||||||
| Subject Keywords: | MEA; rat; mouse; cortex; multi-electrode array; hybrot; animat; voltage-sensitive dye; 2-photon microscopy; culture networks | |||||||||
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| Series Name: | Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society | |||||||||
| DOI: | 10.1109/IEMBS.2003.1280959 | |||||||||
| Record Number: | CaltechAUTHORS:20111020-154335843 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20111020-154335843 | |||||||||
| Official Citation: | Potter, S.M.; Wagenaar, D.A.; Radhika Madhavan; DeMarse, T.B.; , "Long-term bidirectional neuron interfaces for robotic control, and in vitro learning studies," Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE , vol.4, no., pp. 3690- 3693 Vol.4, 17-21 Sept. 2003 doi: 10.1109/IEMBS.2003.1280959 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 27336 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | INVALID USER | |||||||||
| Deposited On: | 21 Oct 2011 17:28 | |||||||||
| Last Modified: | 09 Nov 2021 16:48 |
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