Zhang, David Y. and Yurke, Bernard (2006) A DNA superstructure-based replicator without product inhibition. Natural Computing, 5 (2). pp. 183-202. ISSN 1567-7818. doi:10.1007/s11047-005-4465-x. https://resolver.caltech.edu/CaltechAUTHORS:20111021-090226357
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Abstract
A monomer structure based on a hairpin loop is described that can be linked via short oligonucleotide sequences (linkers) to form polymers. Independence of linked monomers allow for exponential complexity of the polymer structure. A method is described wherein the polymer structure can be replicated semi-conservatively with fidelity, given a source of monomer structures and linkers. Furthermore, the separation of the product from the parent allows for exponential amplification. These steps are achieved by secondary structure constraints and toehold-mediated strand displacement, and occur in the absence of enzymes. The parallel polymerization allows for replication to be achieved in O(log N) time, as opposed to O(N) from a processive process.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2006 Springer. The authors would like to thank Robert Barish and Si-ping Han for proofreading assistance. | |||||||||
| Subject Keywords: | DNA based polymers, DNA motors, self-replication | |||||||||
| Issue or Number: | 2 | |||||||||
| DOI: | 10.1007/s11047-005-4465-x | |||||||||
| Record Number: | CaltechAUTHORS:20111021-090226357 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20111021-090226357 | |||||||||
| Official Citation: | Zhang, D.Y., Yurke, B. A DNA Superstructure-based Replicator without Product Inhibition. Nat Comput 5, 183–202 (2006). https://doi.org/10.1007/s11047-005-4465-x | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 27348 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 24 Oct 2011 21:57 | |||||||||
| Last Modified: | 09 Nov 2021 16:48 |
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