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A DNA superstructure-based replicator without product inhibition

Zhang, David Y. and Yurke, Bernard (2006) A DNA superstructure-based replicator without product inhibition. Natural Computing, 5 (2). pp. 183-202. ISSN 1567-7818. doi:10.1007/s11047-005-4465-x.

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A monomer structure based on a hairpin loop is described that can be linked via short oligonucleotide sequences (linkers) to form polymers. Independence of linked monomers allow for exponential complexity of the polymer structure. A method is described wherein the polymer structure can be replicated semi-conservatively with fidelity, given a source of monomer structures and linkers. Furthermore, the separation of the product from the parent allows for exponential amplification. These steps are achieved by secondary structure constraints and toehold-mediated strand displacement, and occur in the absence of enzymes. The parallel polymerization allows for replication to be achieved in O(log N) time, as opposed to O(N) from a processive process.

Item Type:Article
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URLURL TypeDescription ReadCube access
Yurke, Bernard0000-0003-3913-2855
Additional Information:© 2006 Springer. The authors would like to thank Robert Barish and Si-ping Han for proofreading assistance.
Subject Keywords:DNA based polymers, DNA motors, self-replication
Issue or Number:2
Record Number:CaltechAUTHORS:20111021-090226357
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Official Citation:Zhang, D.Y., Yurke, B. A DNA Superstructure-based Replicator without Product Inhibition. Nat Comput 5, 183–202 (2006).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27348
Deposited By: Tony Diaz
Deposited On:24 Oct 2011 21:57
Last Modified:09 Nov 2021 16:48

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