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Engineering Biological Systems with Synthetic RNA Molecules

Liang, Joe C. and Bloom, Ryan J. and Smolke, Christina D. (2011) Engineering Biological Systems with Synthetic RNA Molecules. Molecular Cell, 43 (6). pp. 915-926. ISSN 1097-2765.

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RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaffolding activities, has highlighted the advantages of RNA as a programmable design substrate. Recent advances in implementing these engineered RNA molecules as key control elements in synthetic genetic networks are highlighting the functional relevance of this class of synthetic elements in programming cellular behaviors.

Item Type:Article
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URLURL TypeDescription DOIArticle
Smolke, Christina D.0000-0002-5449-8495
Additional Information:© 2011 Elsevier Inc. Available online 15 September 2011. C.D.S. is funded by the National Institutes of Health, National Science Foundation (NSF), and Defense Advanced Research Projects Agency. R.J.B. receives funding through a NSF graduate fellowship.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20111025-074935830
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Official Citation:Joe C. Liang, Ryan J. Bloom, Christina D. Smolke, Engineering Biological Systems with Synthetic RNA Molecules, Molecular Cell, Volume 43, Issue 6, 16 September 2011, Pages 915-926, ISSN 1097-2765, 10.1016/j.molcel.2011.08.023. (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27393
Deposited By: Ruth Sustaita
Deposited On:25 Oct 2011 15:01
Last Modified:03 Oct 2019 03:23

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