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Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing

Robison, Craig D. and Jivrajka, Renu V. and Bababeygy, Simon R. and Fink, Wolfgang and Sadun, Alfredo A. and Sebag, J. (2011) Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing. British Journal of Ophthalmology, 95 (10). pp. 1419-1423. ISSN 0007-1161. https://resolver.caltech.edu/CaltechAUTHORS:20111025-093251012

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Abstract

Background/aims: With the increased efficacy of current therapy for wet age-related macular degeneration (AMD), better ways to detect wet AMD are needed. This study was designed to test the ability of three-dimensional contrast threshold Amsler grid (3D-CTAG) testing to distinguish wet AMD from dry AMD. Methods: Conventional paper Amsler grid and 3D-CTAG tests were performed in 90 eyes: 63 with AMD (34 dry, 29 wet) and 27 controls. Qualitative comparisons were based upon the three-dimensional shapes of central visual field (VF) defects. Quantitative analyses considered the number and volume of the three-dimensional defects. Results: 25/34 (74%) dry AMD and 6/29 (21%) wet AMD eyes had no distortions on paper Amsler grid. Of these, 5/25 (20%) dry and 6/6 (100%) wet (p=0.03) AMD eyes exhibited central VF defects with 3D-CTAG. Wet AMD displayed stepped defects in 16/28 (57%) eyes, compared with only 2/34 (6%) of dry AMD eyes (p=0.002). All three volumetric indices of VF defects were two- to four-fold greater in wet than dry AMD (p<0.006). 3D-CTAG had 83.9% positive and 90.6% negative predictive values for wet AMD. Conclusions: 3D-CTAG has a higher likelihood of detecting central VF defects than conventional Amsler grid, especially in wet AMD. Wet AMD can be distinguished from dry AMD by qualitative and quantitative 3D-CTAG criteria. Thus, 3D-CTAG may be useful in screening for wet AMD, quantitating disease severity, and providing a quantitative outcome measure of therapy.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1136/bjo.2010.194886DOIUNSPECIFIED
http://bjo.bmj.com/content/95/10/1419PublisherUNSPECIFIED
Additional Information:© 2011 BMJ Publishing. Accepted 26 December 2010. Published Online First 26 January 2011. The authors thank Laurie Dustin, University of Southern California School of Medicine, Los Angeles, California, for performing the statistical analyses. Funding: VMR Consulting, Inc., Huntington Beach, California, USA (study design; collection, analysis and interpretation of data; writing of article; decision to submit article); NIH grant EY03040 (no involvement in study design, analysis, interpretation, writing, or decision to submit). Contributors: All authors listed have been involved in the conception and design, acquisition of data or analysis and interpretation of data, drafting the article or revising it critically for important intellectual content, and final approval of the version published.
Funders:
Funding AgencyGrant Number
VMR Consulting Inc.UNSPECIFIED
NIHEY03040
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Other Numbering System NameOther Numbering System ID
PMID21270434
Issue or Number:10
Record Number:CaltechAUTHORS:20111025-093251012
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111025-093251012
Official Citation:Robison CD, Jivrajka RV, Bababeygy SR, Fink W, Sadun AA, Sebag J. Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing. Br J Ophthalmol. 2011 Oct;95(10):1419-23. Epub 2011 Jan 26. PubMed PMID: 21270434.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27402
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Oct 2011 17:04
Last Modified:03 Oct 2019 03:23

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