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Agglutination of Sindbis Virus and of Cells Infected with Sindbis Virus by Plant Lectins

Birdwell, Charles R. and Strauss, James H. (1973) Agglutination of Sindbis Virus and of Cells Infected with Sindbis Virus by Plant Lectins. Journal of Virology, 11 (4). pp. 502-507. ISSN 0022-538X. PMCID PMC355130.

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We have examined the agglutination of Sindbis virus and of chick and hamster cells infected with Sindbis virus by two of the plant lectins, concanavalin A and Ricinus communis agglutinin. Both lectins agglutinate the virus by binding to the polysaccharide chains of the envelope glycoproteins. Both chick and hamster cells exhibit increased agglutination by the lectins after infection by Sindbis virus. In the case of chick cells infected with Sindbis virus, this increase in agglutinability occurs between 3 and 5 h after infection. Infected and mock-infected cells bind the same amount of 3H-labeled concanavalin A, which suggests that the increase in agglutination after infection is due to rearrangements at the cell surface rather than to insertion of new lectin binding sites per se.

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Additional Information:Copyright © 1973 by the American Society for Microbiology. Received for publication 16 October 1972 We thank Edith M. Lenches for expert technical assistance and Ellen Strauss for advice in preparing the manuscript. This work was supported by grant GB-31763X from the National Science Foundation and by Public Health Service grant GM-06965 from the National Institute of General Medical Sciences. One of us (C. R. B.) was supported by Public Health Service training grant GM-86 from the National Institute of General Medical Sciences.
Funding AgencyGrant Number
NIH Predoctoral FellowshipGM-86
Issue or Number:4
PubMed Central ID:PMC355130
Record Number:CaltechAUTHORS:BIRjvir73
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2760
Deposited By: Archive Administrator
Deposited On:25 Apr 2006
Last Modified:02 Oct 2019 22:56

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