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Initial Virological and Immunologic Response to Highly Active Antiretroviral Therapy Predicts Long-Term Clinical Outcome

Kitchen, Christina M. and Kitchen, Scott G. and Dubin, Jeffrey A. and Gottlieb, Michael S. (2001) Initial Virological and Immunologic Response to Highly Active Antiretroviral Therapy Predicts Long-Term Clinical Outcome. Clinical Infectious Diseases, 33 (4). pp. 466-472. ISSN 1058-4838. doi:10.1086/321900.

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Little is known about the long-term clinical outcomes for human immunodeficiency virus (HIV)-infected patients who have received highly active antiretroviral therapy (HAART). Determining factors associated with long-term clinical outcomes early in the course of treatment may allow modifications to be made for patients who are at a greater risk of treatment failure. To evaluate these factors, we studied 213 HIV-infected patients who had received HAART for at least 115 weeks. In the univariate analysis, virological response, which was measured as the change in virus load from baseline at month 3 of treatment, was the single best predictor of clinical outcome (relative hazard, 0.722; P = .001), independent of virological suppression. In the multivariate analysis, virological response and immunologic response, which was measured as an increase in CD4 cell count of >200 cells/mm^3, resulted in better prediction of clinical outcomes than did use of either variable alone (P = .02). Our results indicate that changes in virus load and immunologic response together are good predictors of clinical outcome and can be assessed after the initiation of HAART, which would allow clinicians to identify patients early in the course of therapy who are at greater risk of negative outcome.

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Additional Information:© 2001 by the Infectious Diseases Society of America. Received 25 September 2000; revised 20 December 2000; electronically published 11 July 2001. Financial support: National Institutes of Health (grant no. AI07370-09 to C.M.K.).
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Issue or Number:4
Record Number:CaltechAUTHORS:20111104-145104514
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27634
Deposited By: Tony Diaz
Deposited On:04 Nov 2011 22:29
Last Modified:09 Nov 2021 16:50

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