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Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature

Kohandel, M. and Haselwandter, C. A. and Kardar, M. and Sengupta, S. and Sivaloganathan, S. (2011) Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature. Computational and Mathematical Methods in Medicine, 2011 . Art. No. 790721. ISSN 1748-670X.

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The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

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Additional Information:© 2011 M. Kohandel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received 13 July 2010; Accepted 9 January 2011. Academic Editor: Nestor V. Torres. The authors are grateful to G. Powathil for comments on the manuscript. M. Kohandel and S. Sivaloganathan acknowledge financial support by the Natural Sciences and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR). C. A. Haselwandter was supported at MIT by an Erwin Schrödinger fellowship of the Austrian Science Fund, and M. Kardar is supported by the NSF Grant no. DMR-08-03315. S. Sengupta is supported by a DoD Era of Hope Scholar award.
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Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Canadian Institutes of Health Research (CIHR)UNSPECIFIED
FWF Der WissenschaftsfondsUNSPECIFIED
Department of Defense (DoD)UNSPECIFIED
Record Number:CaltechAUTHORS:20111107-084221045
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27641
Deposited By: Tony Diaz
Deposited On:07 Nov 2011 19:39
Last Modified:18 May 2020 16:07

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