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Genetic Recombination in Bacteriophage {varphi}X174

Benbow, Robert M. and Zuccarelli, Anthony J. and Davis, Gloria C. and Sinsheimer, Robert L. (1974) Genetic Recombination in Bacteriophage {varphi}X174. Journal of Virology, 13 (4). pp. 898-907. ISSN 0022-538X. PMCID PMC355388.

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Genetic recombination in bacteriophage {varphi}X174 usually takes place early in the infection process and involves two parental replicative form (double-stranded) DNA molecules. The host recA protein is required; none of the nine known {varphi}X174 cistron products is essential. The products of a single recombination event are nonreciprocal and asymmetric. Typically, only one of the parental genotypes and one recombinant genotype are recovered from a single cell. An alternative, less efficient recombination mechanism which requires an active {varphi}X174 cistron A protein is observed in the absence of the host recA gene product.

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Additional Information:© 1974 American Society for Microbiology. Received for publication 25 October 1973 For the initial idea to study genetic recombination in phiX174 we are grateful to Paul Howard-Flanders. We have appreciated several exchanges regarding small phage genetic recombination with Ethel and Irwin Tessman. The excellent technical assistance of Jill Fabricant Hiatt and Alma J. Shafer is acknowledged. A preliminary account of these results was given at the Bacteriophage Meetings, Cold Spring Harbor, 26 to 31 August, 1971. This research was carried out with the assistance of Public Health Service training grant GM-86 and research grant GM 13554 from the National Institute of General Medical Sciences.
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NIH Predoctoral FellowshipGM-86
Issue or Number:4
PubMed Central ID:PMC355388
Record Number:CaltechAUTHORS:BENjvir74
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2765
Deposited By: Archive Administrator
Deposited On:26 Apr 2006
Last Modified:02 Oct 2019 22:56

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