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Long-range mechanical force in colony branching and tumor invasion

Guo, Chin-Lin and Ouyang, Mingxing and Yu, Jiun-Yann and Price, Andrew and Maslov, Jordan (2011) Long-range mechanical force in colony branching and tumor invasion. In: Biosensing and Nanomedicine IV. Proceedings of SPIE. No.8099. SPIE , Bellingham, WA, Art. No. 809903. ISBN 9780819487094.

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The most concerned factors for cancer prognosis are tumor invasion and metastasis. The patterns of tumor invasion can be characterized as random infiltration to surrounding extracellular matrix (ECM) or formation of long-range path for collective migration. Recent studies indicate that mechanical force plays an important role in tumor infiltration and collective migration. However, how tumor colonies develop mechanical interactions with each other to initiate various invasion patterns is unclear. Using a micro-patterning technique, we partition cells into clusters to mimic tumor colonies and quantitatively induce colony-ECM interactions. We find that pre-malignant epithelial cells, in response to concentrations of type I collagen in ECM ([COL]), develop various branching patterns resembling those observed in tumor invasion. In contrast with conventional thought, these patterns require long-range (~ 600 μm) transmission of traction force, but not biochemical factors. At low [COL], cell colonies synergistically develop pairwise and directed branching mimicking the formation of long-range path. By contrast, at high [COL] or high colony density, cell colonies develop random branching and scattering patterns independent of each other. Our results suggest that tumor colonies might select different invasive patterns depending on their interactions with each other and with the ECM.

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Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Online Sep 12, 2011.
Subject Keywords:mechanical force, long-range, extracellular matrix, branching morphogenesis, tumor invasion, spatial pattern
Series Name:Proceedings of SPIE
Issue or Number:8099
Record Number:CaltechAUTHORS:20111107-141527848
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Official Citation:Chin-Lin Guo, Mingxing Ouyang, Jiun-Yann Yu, Andrew Price and Jordan Maslov, "Long-range mechanical force in colony branching and tumor invasion", Proc. SPIE 8099, 809903 (2011); doi:10.1117/12.911904
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27659
Deposited By: Tony Diaz
Deposited On:08 Nov 2011 23:31
Last Modified:03 Oct 2019 03:25

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