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An optical coherence microscope for 3-dimensional imaging in developmental biology

Hoeling, Barbara M. and Fernandez, Andrew D. and Haskell, Richard C. and Huang, Erik and Myers, Whittier R. and Petersen, Daniel C. and Ungersma, Sharon E. and Wang, Ruye and Williams, Mary E. and Fraser, Scott E. (2000) An optical coherence microscope for 3-dimensional imaging in developmental biology. Optics Express, 6 (7). pp. 136-146. ISSN 1094-4087.

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An optical coherence microscope (OCM) has been designed and constructed to acquire 3-dimensional images of highly scattering biological tissue. Volume-rendering software is used to enhance 3-D visualization of the data sets. Lateral resolution of the OCM is 5 mm (FWHM), and the depth resolution is 10 mm (FWHM) in tissue. The design trade-offs for a 3-D OCM are discussed, and the fundamental photon noise limitation is measured and compared with theory. A rotating 3-D image of a frog embryo is presented to illustrate the capabilities of the instrument.

Item Type:Article
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URLURL TypeDescription
Fraser, Scott E.0000-0002-5377-0223
Additional Information:©2000 Optical Society of America. Received February 02, 2000; Revised March 20, 2000. Support for this work has been provided by a Special Opportunity Award from the Whitaker Foundation to Harvey Mudd College and by a National Science Foundation Grant DBI-9612240.
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
Subject Keywords:OCIS codes: (170.4500) Optical coherence tomography; (170.6900) Three-dimensional microscopy; (110.6880) Three-dimensional image acquisition; (120.3180) Interferometry
Issue or Number:7
Record Number:CaltechAUTHORS:HOEoe02
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:278
Deposited By: Archive Administrator
Deposited On:16 May 2005
Last Modified:02 Oct 2019 22:32

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