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ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase

Mui, Timothy P. and Fuss, Jill O. and Ishida, Justin P. and Tainer, John A. and Barton, Jacqueline K. (2011) ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase. Journal of the American Chemical Society, 133 (41). pp. 16378-16381. ISSN 0002-7863. PMCID PMC3234108. https://resolver.caltech.edu/CaltechAUTHORS:20111116-102627735

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Abstract

Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription. The DNA-mediated redox signal resembles that of base excision repair proteins, with a DNA-bound redox potential of ~80 mV versus NHE. Significantly, this signal increases with ATP hydrolysis. Moreover, the redox signal is substrate-dependent, reports on the DNA conformational changes associated with enzymatic function, and may reflect a general biological role for DNA charge transport.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja207222tDOIArticle
http://pubs.acs.org/doi/full/10.1021/ja207222tPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234108/PubMed CentralArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2011 American Chemical Society. Received: August 1, 2011. Publication Date (Web): September 22, 2011. This research was supported by the NIH (GM49216 to J.K.B. and CA112093 to J.A.T.) and the DOE (ENIGMA program under Contract No. DE-AC02-05CH11231 to J.A.T.). T.P.M. also thanks the NSF for a graduate fellowship.
Funders:
Funding AgencyGrant Number
NIHGM49216
NIHCA112293
Department of Energy (DOE)DE-AC02-05CH11231
NSF Graduate FellowshipUNSPECIFIED
Issue or Number:41
PubMed Central ID:PMC3234108
Record Number:CaltechAUTHORS:20111116-102627735
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111116-102627735
Official Citation:ATP-Stimulated, DNA-Mediated Redox Signaling by XPD, a DNA Repair and Transcription Helicase Timothy P. Mui, Jill O. Fuss, Justin P. Ishida, John A. Tainer, and Jacqueline K. Barton Journal of the American Chemical Society 2011 133 (41), 16378-16381
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27803
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Nov 2011 18:48
Last Modified:03 Oct 2019 03:26

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