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Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum

Tyszka, J. Michael and Kennedy, Daniel P. and Adolphs, Ralph and Paul, Lynn K. (2011) Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum. Journal of Neuroscience, 31 (42). pp. 15154-15162. ISSN 0270-6474. PMCID PMC3221732. https://resolver.caltech.edu/CaltechAUTHORS:20111116-104400183

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Abstract

Temporal correlations between different brain regions in the resting-state BOLD signal are thought to reflect intrinsic functional brain connectivity (Biswal et al., 1995; Greicius et al., 2003; Fox et al., 2007). The functional networks identified are typically bilaterally distributed across the cerebral hemispheres, show similarity to known white matter connections (Greicius et al., 2009), and are seen even in anesthetized monkeys (Vincent et al., 2007). Yet it remains unclear how they arise. Here we tested two distinct possibilities: (1) functional networks arise largely from structural connectivity constraints, and generally require direct interactions between functionally coupled regions mediated by white-matter tracts; and (2) functional networks emerge flexibly with the development of normal cognition and behavior and can be realized in multiple structural architectures. We conducted resting-state fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intelligence, and compared their data to those from eight healthy matched controls. We performed three main analyses: anatomical region-of-interest-based correlations to test homotopic functional connectivity, independent component analysis (ICA) to reveal functional networks with a data-driven approach, and ICA-based interhemispheric correlation analysis. Both groups showed equivalently strong homotopic BOLD correlation. Surprisingly, almost all of the group-level independent components identified in controls were observed in AgCC and were predominantly bilaterally symmetric. The results argue that a normal complement of resting-state networks and intact functional coupling between the hemispheres can emerge in the absence of the corpus callosum, favoring the second over the first possibility listed above.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1523/JNEUROSCI.1453-11.2011 DOIArticle
http://www.jneurosci.org/content/31/42/15154.abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221732/PubMed CentralArticle
ORCID:
AuthorORCID
Tyszka, J. Michael0000-0001-9342-9014
Kennedy, Daniel P.0000-0002-5915-0893
Adolphs, Ralph0000-0002-8053-9692
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© 2011 The Authors. Received March 22, 2011; revised Aug. 1, 2011; accepted Aug. 18, 2011. This work was supported by the Simons Foundation (SFARI-07-01 to R.A.), the National Institute of Mental Health (R01 MH080721 to R.A.), and the National Alliance for Research on Schizophrenia and Depression (2009 Young Investigator Award to L.K.P.). We thank Pratik Mukherjee, Elliott Sherr, and Leo Li for helpful discussions regarding this work. We also thank the participants for their invaluable contribution to this research. Author contributions: J.M.T., D.P.K., R.A., and L.K.P. designed research; J.M.T. performed research; J.M.T. analyzed data; J.M.T., D.P.K., R.A., and L.K.P. wrote the paper.
Funders:
Funding AgencyGrant Number
Simons FoundationSFARI-07-01
NIHR01 MH080721
National Alliance for Research on Schizophrenia and DepressionUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:42
PubMed Central ID:PMC3221732
Record Number:CaltechAUTHORS:20111116-104400183
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111116-104400183
Official Citation:J. Michael Tyszka, Daniel P. Kennedy, Ralph Adolphs, and Lynn K. Paul Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum The Journal of Neuroscience, 19 October 2011, 31(42):15154-15162; doi:10.1523/JNEUROSCI.1453-11.2011
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27804
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 Nov 2011 19:04
Last Modified:03 Oct 2019 03:26

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