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Transformation of stimulus value signals into motor commands during simple choice

Hare, Todd A. and Schultz, Wolfram and Camerer, Colin F. and O'Doherty, John P. and Rangel, Antonio (2011) Transformation of stimulus value signals into motor commands during simple choice. Proceedings of the National Academy of Sciences of the United States of America, 108 (44). pp. 18120-18125. ISSN 0027-8424. PMCID PMC3207676. doi:10.1073/pnas.1109322108. https://resolver.caltech.edu/CaltechAUTHORS:20111121-162421290

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Abstract

Decision-making can be broken down into several component processes: assigning values to stimuli under consideration, selecting an option by comparing those values, and initiating motor responses to obtain the reward. Although much is known about the neural encoding of stimulus values and motor commands, little is known about the mechanisms through which stimulus values are compared, and the resulting decision is transmitted to motor systems. We investigated this process using human fMRI in a task where choices were indicated using the left or right hand. We found evidence consistent with the hypothesis that value signals are computed in the ventral medial prefrontal cortex, they are passed to regions of dorsomedial prefrontal cortex and intraparietal sulcus, implementing a comparison process, and the output of the comparator regions modulates activity in motor cortex to implement the choice. These results describe the network through which stimulus values are transformed into actions during a simple choice task.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1109322108 DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207676/PubMed CentralArticle
http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1109322108/-/DCSupplementalPublisherSupporting Information
ORCID:
AuthorORCID
Camerer, Colin F.0000-0003-4049-1871
O'Doherty, John P.0000-0003-0016-3531
Additional Information:© 2011 National Academy of Sciences. Edited by William T. Newsome, Stanford University, Stanford, CA, and approved September 20, 2011 (received for review June 10, 2011). Published online before print October 17, 2011. We thank the Betty and Gordon Moore Foundation (C.F.C., J.P.O., and A.R.) for financial support as well as the National Science Foundation (A.R.). Author contributions: T.A.H., W.S., C.F.C., J.P.O., and A.R. designed research; T.A.H. performed research; T.A.H. and A.R. analyzed data; and T.A.H., W.S., C.F.C., J.P.O., and A.R. wrote the paper.
Funders:
Funding AgencyGrant Number
Gordon and Betty Moore FoundationUNSPECIFIED
NSFUNSPECIFIED
Subject Keywords:dynamic causal modeling; valuation
Issue or Number:44
PubMed Central ID:PMC3207676
DOI:10.1073/pnas.1109322108
Record Number:CaltechAUTHORS:20111121-162421290
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111121-162421290
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:27898
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:22 Nov 2011 15:54
Last Modified:09 Nov 2021 16:52

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