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Antibody to a host protein prevents initiation by the poliovirus replicase

Dasgupta, Asim and Hollingshead, Philip and Baltimore, David (1982) Antibody to a host protein prevents initiation by the poliovirus replicase. Journal of Virology, 42 (3). pp. 1114-1117. ISSN 0022-538X.

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In vitro transcription of poliovirus RNA was catalyzed by the combination of a virus-coded polymerase and a host cell protein (host factor). Antibody to host factor inhibited template-dependent synthesis of complementary RNA where presumably RNA chain initiation occurred. On the contrary, elongation of already initiated RNA chains catalyzed by the replicase-template complex was not inhibited by anti-host factor antibody. These results strongly favored our previous notion that the host factor was needed for the initiation step of viral complementary RNA synthesis.

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Baltimore, David0000-0001-8723-8190
Additional Information:Copyright © 1982 by the American Society for Microbiology. Received 26 October 1981/Accepted 1 February 1982 This work was supported by Public Health Service grant AI 08388 from the National Institute of Allergy and Infectious Diseases to D.B. and by grant G810612 from the California Institute for Cancer Research to A.D. D.B. is an American Cancer Society Research Professor. We gratefully acknowledge the technical assistance of Heinrich Kolbel and Mary Taw.
Issue or Number:3
Record Number:CaltechAUTHORS:DASjvir82
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:2798
Deposited By: Archive Administrator
Deposited On:27 Apr 2006
Last Modified:02 Oct 2019 22:56

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