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Color Capable Sub-Pixel Resolving Optofluidic Microscope and Its Application to Blood Cell Imaging for Malaria Diagnosis

Lee, Seung Ah and Leitao, Ricardo and Zheng, Guoan and Yang, Samuel and Rodriguez, Ana and Yang, Changhuei (2011) Color Capable Sub-Pixel Resolving Optofluidic Microscope and Its Application to Blood Cell Imaging for Malaria Diagnosis. PLoS ONE, 6 (10). Art. No. e26127. ISSN 1932-6203. PMCID PMC3191177. https://resolver.caltech.edu/CaltechAUTHORS:20111207-094726805

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Abstract

Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 µm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pone.0026127 DOIArticle
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026127PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191177/PubMed CentralArticle
Additional Information:© 2011 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received May 20, 2011; Accepted September 20, 2011; Published October 11, 2011. Editor: Arum Han, Texas A&M University, United States of America. Funding: This work was supported by a grant from the Gates Foundation (OPP1007336 GCE). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful for the constructive discussions with and generous help from Dr. Benjamin Judkewitz and Mr. Shuo Pang from Caltech. Author Contributions: Conceived and designed the experiments: SAL RL GZ SY AR CY. Performed the experiments: SAL RL. Analyzed the data: GZ SY.
Funders:
Funding AgencyGrant Number
Bill and Melinda Gates FoundationOPP1007336
Issue or Number:10
PubMed Central ID:PMC3191177
Record Number:CaltechAUTHORS:20111207-094726805
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111207-094726805
Official Citation:Lee SA, Leitao R, Zheng G, Yang S, Rodriguez A, et al. (2011) Color Capable Sub-Pixel Resolving Optofluidic Microscope and Its Application to Blood Cell Imaging for Malaria Diagnosis. PLoS ONE 6(10): e26127. doi:10.1371/journal.pone.0026127
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:28338
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Dec 2011 23:05
Last Modified:03 Oct 2019 03:31

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