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Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor

Spatzal, Thomas and Aksoyoglu, Müge and Zhang, Limei and Andrade, Susana L. A. and Schleicher, Erik and Weber, Stefan and Rees, Douglas C. and Einsle, Oliver (2011) Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor. Science, 334 (6058). p. 940. ISSN 0036-8075. PMCID PMC3268367. https://resolver.caltech.edu/CaltechAUTHORS:20111207-101914652

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Abstract

The identity of the interstitial light atom in the center of the FeMo cofactor of nitrogenase has been enigmatic since its discovery. Atomic-resolution x-ray diffraction data and an electron spin echo envelope modulation (ESEEM) analysis now provide direct evidence that the ligand is a carbon species.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.1214025DOIArticle
http://www.sciencemag.org/content/334/6058/940.abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268367/PubMed CentralArticle
ORCID:
AuthorORCID
Spatzal, Thomas0000-0002-9136-5915
Rees, Douglas C.0000-0003-4073-1185
Additional Information:© 2011 American Association for the Advancement of Science. Received 15 September 2011; accepted 19 October 2011. We thank the staff at Swiss Light Source, Villigen, Switzerland, and S. M. Consiglio for assistance with the calculations. The work was supported by Deutsche Forschungsgemeinschaft (grants Ei-520/7 to O.E., An-676/1 to S.L.A.A., and IRTG 1478), Natural Sciences and Engineering Research Council of Canada postdoctoral fellowship to L.Z., NIH (grant GM45162 to D.C.R.), and HHMI (to D.C.R.). The structural model and structure factors have been deposited with the Protein Data Bank (accession code 3U7Q).
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)Ei-520/7
Deutsche Forschungsgemeinschaft (DFG)An-676/1
Deutsche Forschungsgemeinschaft (DFG)IRTG 1478
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
NIHGM45162
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Protein Bank accession code3U7Q
Issue or Number:6058
PubMed Central ID:PMC3268367
Record Number:CaltechAUTHORS:20111207-101914652
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111207-101914652
Official Citation:Evidence for Interstitial Carbon in Nitrogenase FeMo Cofactor Thomas Spatzal, Müge Aksoyoglu, Limei Zhang, Susana L. A. Andrade, Erik Schleicher, Stefan Weber, Douglas C. Rees, and Oliver Einsle Science 18 November 2011: 940.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:28340
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Dec 2011 18:45
Last Modified:14 Oct 2019 18:22

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