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From elementary synaptic circuits to information processing in primary auditory cortex

Wu, Guangying K. and Tao, Huizhong W. and Zhang, Li I. (2011) From elementary synaptic circuits to information processing in primary auditory cortex. Neuroscience and Biobehavioral Reviews, 35 (10). pp. 2094-2104. ISSN 0149-7634. https://resolver.caltech.edu/CaltechAUTHORS:20111207-131843447

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Abstract

A key for understanding how information is processed in the cortex is to unravel the dauntingly complex cortical neural circuitry. Recent technical innovations, in particular the in vivo whole-cell voltage-clamp recording techniques, make it possible to directly dissect the excitatory and inhibitory inputs underlying an individual cortical neuron’s processing function. This method provides an essential complement to conventional approaches, with which the transfer functions of the neural system are derived by correlating neuronal spike outputs to sensory inputs. Here, we intend to introduce a potentially systematic strategy for resolving the structure of functional synaptic circuits. As complex circuits can be built upon elementary modules, the primary focus of this strategy is to identify elementary synaptic circuits and determine how these circuit units contribute to specific processing functions. This review will summarize recent studies on functional synaptic circuits in the primary auditory cortex, comment on existing experimental techniques for in vivo circuitry studies, and provide a perspective on immediate future directions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.neubiorev.2011.05.004DOIUNSPECIFIED
http://www.sciencedirect.com/science/article/pii/S0149763411000868PublisherUNSPECIFIED
Additional Information:© 2011 Elsevier Ltd. Received 1 October 2010; revised 4 May 2011; Accepted 9 May 2011. Available online 14 May 2011. This work was supported by National Institute of Health (DC008983, DC008588, EY019049), the Searle Scholar Program, the Esther A. and Joseph Klingenstein Fund, and the David and Lucile Packard Foundation. G.K.W. is a Broad Fellow.
Funders:
Funding AgencyGrant Number
NIHDC008983
NIHDC008588
NIHEY019049
Searle Scholar ProgramUNSPECIFIED
Esther A. and Joseph Klingestein FundUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Subject Keywords:Primary auditory cortex; Microcircuit; Cortical processing; Voltage-clamp recording; Balanced excitation and inhibition; Functional synaptic circuit; Frequency tuning; Intensity tuning; Direction selectivity
Issue or Number:10
Record Number:CaltechAUTHORS:20111207-131843447
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20111207-131843447
Official Citation:Guangying K. Wu, Huizhong W. Tao, Li I. Zhang, From elementary synaptic circuits to information processing in primary auditory cortex, Neuroscience & Biobehavioral Reviews, Volume 35, Issue 10, November 2011, Pages 2094-2104, ISSN 0149-7634, 10.1016/j.neubiorev.2011.05.004. (http://www.sciencedirect.com/science/article/pii/S0149763411000868)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:28354
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Dec 2011 21:38
Last Modified:03 Oct 2019 03:31

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