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Two nested gonadal inductions of the vulva in nematodes

Félix, Marie-Anne and Sternberg, Paul W. (1997) Two nested gonadal inductions of the vulva in nematodes. Development, 124 (1). pp. 253-259. ISSN 0950-1991.

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How do intercellular signals that pattern cell fates vary in evolution? During nematode vulva development, precursor cells acquire one of three fates in a pattern centered around the gonadal anchor cell. Non-vulval fates are at the periphery, outer and inner vulval fates are towards the center. In Caenorhabditis elegans, the three fates are specified around the same time by an induction by the anchor cell and lateral signaling between the vulva precursor cells. We find that, in three other nematode species (Panagrolaimus, Oscheius and Rhabditella spp.) spanning two families, the centered pattern is obtained by two temporally distinct gonadal inductions. The first induction specifies vulval fates; the second induction specifies the inner vulval fates in a subset of the precursors’ daughters. This evolutionary change in the spatiotemporal connectivity of cell interactions allows centering of the pattern between two precursors in Panagrolaimus.

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Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 1997 The Company of Biologists Limited. Accepted 23 September 1996. We thank L. Carta, J. DeModena, D. Fitch, W. Sudhaus and W. Wood for worm strains, R. Sommer, K. Tietze and M. Wang for sharing unpublished observations, and T. Clandinin, D. Dimster-Denk, M. Friedrich, J. Liu and R. Sommer for comments on the manuscript. M.-A. F. is supported by an HFSP fellowship. P. W. S. is an investigator with the Howard Hughes Medical Institute.
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Subject Keywords:nematode; evolution; vulva; patterning; induction; gonad; anchor cell
Issue or Number:1
Record Number:CaltechAUTHORS:20120118-110011891
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:28827
Deposited By: Tony Diaz
Deposited On:19 Jan 2012 19:47
Last Modified:03 Mar 2020 13:01

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