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The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis

Clark, Steven E. and Jacobsen, Steven E. and Levin, Joshua Z. and Meyerowitz, Elliot M. (1996) The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis. Development, 122 (5). pp. 1567-1575. ISSN 0950-1991.

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The CLAVATA (CLV1 and CLV3) and SHOOT MERISTEMLESS (STM) genes specifically regulate shoot meristem development in Arabidopsis. CLV and STH appear to have opposite functions: c1v1 and Clv3 mutants accumulate excess undifferentiated cells in the shoot and floral meristem, while stm mutants fail to form the undifferentiated cells of the shoot meristem during embryonic development. We have identified a weak allele of stm (stm-2) that reveals STM is not only required for the establish- ment of the shoot meristem, but is also required for the continued maintenance of undifferentiated cells in the shoot meristem and for proper proliferation of cells in the floral meristem. We have found evidence of genetic interactions between the CLV and STM loci. clv1 and c1v3 mutations partially suppressed the stm-1 and stm-2 phenotypes, and were capable of suppression in a dominant fashion. clv stm double mutants and plants homozygous for stm but heterozygous for clv, while still lacking an embryonic shoot meristem, exhibited greatly enhanced postembryonic shoot and floral meristem development. Although stm phenotypes are recessive, stm mutations dominantly suppressed clv homozygous and heterozygous phenotypes. These results indicate that the stm phenotype is sensitive to the levels of CLV activity, while the clv phenotype is sensitive to the level of STM activity. We propose that these genes play related but opposing roles in the regulation of cell division and/or cell differentiation in shoot and floral meristems.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1996 The Company of Biologists Limited. Accepted 5 February 1996. The authors would like to thank members of the Meyerowitz and Schiefelbein labs for critical reading of the manuscript, and Thomas Laux for challenging discussions on the nature of meristems. This material is based upon work supported by NSF grant MCB-9204839 and an award from the Strategic Research Fund of Zeneca Seeds to E. M. M., by NSF grant IBN 9419457 to S. E. C., and by postdoctoral fellowships to S. E. C. (NSF, DIR-9104342), S. E. J. (NIH, GM15964) and J. Z. L. (NIH, GM15132). The scanning electron microscope used at the University of Michigan was acquired under grant #BSR-83-14092 from the NSF. S. E. C was and S. E. J. is currently a Zeneca Fellow.
Funding AgencyGrant Number
NSF Postdoctoral FellowshipDIR-9104342
NIH Postdoctoral FellowshipGM15964
NIH Postdoctoral FellowshipGM15132
Subject Keywords:organogenesis; cell division; cell differentiation; pattern formation; CLAVATA; SHOOT MERISTEMLESS; Arabidopsis; meristem
Issue or Number:5
Record Number:CaltechAUTHORS:20120126-134339702
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Official Citation:The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis S.E. Clark, S.E. Jacobsen, J.Z. Levin, E.M. Meyerowitz Development 1996 122: 1567-1575
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:28986
Deposited By: Tony Diaz
Deposited On:31 Jan 2012 00:20
Last Modified:03 Oct 2019 03:37

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