Rosenthal, Adam Z. and Elowitz, Michael B. (2012) Following evolution of bacterial antibiotic resistance in real time. Nature Genetics, 44 (1). pp. 11-13. ISSN 1061-4036. doi:10.1038/ng.1048. https://resolver.caltech.edu/CaltechAUTHORS:20120203-102759226
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Abstract
A new study reports the development of the ‘morbidostat’, a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.
| Item Type: | Article | |||||||||
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| Additional Information: | © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 27 December 2011. The authors declare no competing financial interests. | |||||||||
| Issue or Number: | 1 | |||||||||
| DOI: | 10.1038/ng.1048 | |||||||||
| Record Number: | CaltechAUTHORS:20120203-102759226 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20120203-102759226 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 29121 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 03 Feb 2012 18:48 | |||||||||
| Last Modified: | 09 Nov 2021 17:04 |
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