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Following evolution of bacterial antibiotic resistance in real time

Rosenthal, Adam Z. and Elowitz, Michael B. (2012) Following evolution of bacterial antibiotic resistance in real time. Nature Genetics, 44 (1). pp. 11-13. ISSN 1061-4036. doi:10.1038/ng.1048.

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A new study reports the development of the ‘morbidostat’, a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.

Item Type:Article
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Rosenthal, Adam Z.0000-0002-6936-3665
Elowitz, Michael B.0000-0002-1221-0967
Additional Information:© 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 27 December 2011. The authors declare no competing financial interests.
Issue or Number:1
Record Number:CaltechAUTHORS:20120203-102759226
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29121
Deposited By: Ruth Sustaita
Deposited On:03 Feb 2012 18:48
Last Modified:09 Nov 2021 17:04

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