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Functional division of hippocampal area CA1 via modulatory gating of entorhinal cortical inputs

Ito, Hiroshi T. and Schuman, Erin M. (2012) Functional division of hippocampal area CA1 via modulatory gating of entorhinal cortical inputs. Hippocampus, 22 (2). pp. 372-387. ISSN 1050-9631. https://resolver.caltech.edu/CaltechAUTHORS:20120210-100326980

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Abstract

The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional segregation of area CA1, however, remains relatively unexplored. Here, we demonstrated differential novelty-induced c-Fos expression along the transverse-axis of area CA1 corresponding to topographic projections of MEC and LEC inputs. We found that, while novel place exposure induced a uniform c-Fos expression along the transverse-axis of area CA1, novel object exposure primarily activated the distal half of CA1 neurons. In hippocampal slices, we observed distinct presynaptic properties between LEC and MEC terminals, and application of either DA or NE produced a largely selective influence on one set of inputs (LEC). Finally, we demonstrated that differential c-Fos expression along the transverse axis of area CA1 was largely abolished by an antagonist of neuromodulatory receptors, clozapine. Our results suggest that neuromodulators can control topographic TA projections allowing the hippocampus to differentially encode new information along the transverse axis of area CA1.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/hipo.20909DOIUNSPECIFIED
http://onlinelibrary.wiley.com/doi/10.1002/hipo.20909/abstractPublisherUNSPECIFIED
ORCID:
AuthorORCID
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 2011 Wiley Periodicals, Inc. Issue published online: 19 January 2012; Article first published online: 14 January 2011; Manuscript Accepted: 29 September 2010. We thank the members of the Schuman laboratory for discussions. E.M.S. was an Investigator of the Howard Hughes Medical Institute.
Subject Keywords:temporoammonic pathway; medial/lateral entorhinal cortex; spatial/nonspatial information; dopamine; norepinephrine
Issue or Number:2
Record Number:CaltechAUTHORS:20120210-100326980
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120210-100326980
Official Citation:Ito, H. T. and Schuman, E. M. (2012), Functional division of hippocampal area CA1 via modulatory gating of entorhinal cortical inputs. Hippocampus, 22: 372–387. doi: 10.1002/hipo.20909
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29235
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:10 Feb 2012 19:33
Last Modified:09 Mar 2020 13:19

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