CaltechAUTHORS
  A Caltech Library Service

T-cell identity and epigenetic memory

Rothenberg, Ellen V. and Zhang, Jingli A. (2012) T-cell identity and epigenetic memory. In: Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. No.356. Springer Verlag , pp. 117-143. ISBN 9783642241024. PMCID PMC3679184. https://resolver.caltech.edu/CaltechAUTHORS:20120213-081638601

[img] PDF - Accepted Version
See Usage Policy.

1MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20120213-081638601

Abstract

T-cell development endows cells with a flexible range of effector differentiation options, superimposed on a stable core of lineage-specific gene expression that is maintained while access to alternative hematopoietic lineages is permanently renounced. This combination of features could be explained by environmentally responsive transcription factor mobilization overlaying an epigenetically stabilized base gene expression state. For example, "poising" of promoters could offer preferential access to T-cell genes, while repressive histone modifications and DNA methylation of non-T regulatory genes could be responsible for keeping non-T developmental options closed. Here, we critically review the evidence for the actual deployment of epigenetic marking to support the stable aspects of T-cell identity. Much of epigenetic marking is dynamically maintained or subject to rapid modification by local action of transcription factors. Repressive histone marks are used in gene-specific ways that do not fit a simple, developmental lineage-exclusion hierarchy. We argue that epigenetic analysis may achieve its greatest impact for illuminating regulatory biology when it is used to locate cis-regulatory elements by catching them in the act of mediating regulatory change.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/82_2011_168DOIArticle
http://www.springerlink.com/content/j1477480k0407655/PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679184/PubMed CentralArticle
ORCID:
AuthorORCID
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2011 Springer-Verlag Berlin Heidelberg. We gratefully acknowledge Georgi Marinov and Ali Mortazavi for help with software conversions between mm8 and mm9 mouse genomic coordinates, and members of the Rothenberg lab for stimulating discussions. The authors were supported by grants from the NIH, 5RC2 CA148278-02 and 3R01CA090233-08S1, and by the Albert Billings Ruddock Professorship (E.V.R.) at the California Institute of Technology.
Funders:
Funding AgencyGrant Number
NIH5RC2 CA148278-02
NIH3R01CA090233-08S1
Caltech Albert Billings Ruddock ProfessorshipUNSPECIFIED
Series Name:Current Topics in Microbiology and Immunology
Issue or Number:356
PubMed Central ID:PMC3679184
DOI:10.1007/82_2011_168
Record Number:CaltechAUTHORS:20120213-081638601
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120213-081638601
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29252
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Feb 2012 17:38
Last Modified:09 Nov 2021 17:05

Repository Staff Only: item control page