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Genetics of fat storage in flies and worms: what went wrong?

Al-Anzi, Bader and Zinn, Kai (2011) Genetics of fat storage in flies and worms: what went wrong? Frontiers in Genetics, 2 . Art. No. 87. ISSN 1664-8021. PMCID PMC3268639. https://resolver.caltech.edu/CaltechAUTHORS:20120213-083055152

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Abstract

Body weight and fat storage are strongly influenced by an individual’s genetic makeup. In humans, genetic polymorphisms have been identified that have effects on body mass index (BMI) and fat content (Meyre et al., 2009; Speliotes et al., 2010; Choquet and Meyre, 2011a), and studies of monogenic rodent models of obesity have defined a variety of genes and signaling pathways that control fat storage and metabolism (Barsh and Schwartz, 2002). However, many other genes that regulate these processes undoubtedly remain to be discovered. Although forward genetic screens in the mouse have the potential to identify new obesity genes, such screens are expensive and lengthy endeavors.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3389/fgene.2011.00087DOIArticle
http://www.frontiersin.org/Genomic_Endocrinology/10.3389/fgene.2011.00087/fullPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268639/PubMed CentralArticle
ORCID:
AuthorORCID
Zinn, Kai0000-0002-6706-5605
Additional Information:© 2011 Al-Anzi and Zinn. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. This article was submitted to Frontiers in Genomic Endocrinology, a specialty of Frontiers in Genetics. Received: 19 May 2011; accepted: 15 November 2011; published online: 01 December 2011.
PubMed Central ID:PMC3268639
Record Number:CaltechAUTHORS:20120213-083055152
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120213-083055152
Official Citation:Al-Anzi B and Zinn K (2011) Genetics of fat storage in flies and worms: what went wrong? Front. Gene. 2:87. doi: 10.3389/fgene.2011.00087
Usage Policy:This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non- commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
ID Code:29253
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Mar 2012 20:32
Last Modified:03 Oct 2019 03:39

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