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Flow-enhanced transient response in whispering gallery mode biosensors

Gamba, Jason M. and Flagan, Richard C. (2011) Flow-enhanced transient response in whispering gallery mode biosensors. Applied Physics Letters, 99 (25). Art. No. 253705. ISSN 0003-6951. doi:10.1063/1.3669698.

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Whispering gallery mode (WGM) optical resonator sensors are an extremely sensitive label-free technology for detecting the binding of biomolecules in solution. To better understand the fast transient response observed with these devices, we model mass transfer to spherical and toroidal WGM sensors of identical outer radius. Finite element simulations predict a 3-10 fold higher binding frequency for toroidal sensors. These results agree to within an order of magnitude with experimental data from the literature and suggest a design strategy to improve the transient response of a sensor by making the device small only in the dimension that governs boundary layer development.

Item Type:Article
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URLURL TypeDescription DOIArticle
Flagan, Richard C.0000-0001-5690-770X
Additional Information:© 2011 American Institute of Physics. Received 1 September 2011; accepted 11 November 2011; published online 21 December 2011. This work was supported by funding from the Jacobs Institute for Molecular Engineering for Medicine at the California Institute of Technology.
Funding AgencyGrant Number
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Subject Keywords:biochemistry, biosensors, finite element analysis, mass transfer, molecular biophysics, optical resonators, optical sensors, whispering gallery modes
Issue or Number:25
Classification Code:PACS: 87.80.-y; 87.15.N-; 42.79.-e; 07.07.Df
Record Number:CaltechAUTHORS:20120213-110848252
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29257
Deposited By: Tony Diaz
Deposited On:14 Feb 2012 00:21
Last Modified:09 Nov 2021 17:05

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