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Spiking and LFP activity in PRR during symbolically instructed reaches

Hwang, Eun Jung and Andersen, Richard A. (2012) Spiking and LFP activity in PRR during symbolically instructed reaches. Journal of Neurophysiology, 107 (3). pp. 836-849. ISSN 0022-3077. PMCID PMC3289477. doi:10.1152/jn.00063.2011. https://resolver.caltech.edu/CaltechAUTHORS:20120214-111532983

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Abstract

The spiking activity in the parietal reach region (PRR) represents the spatial goal of an impending reach when the reach is directed toward or away from a visual object. The local field potentials (LFPs) in this region also represent the reach goal when the reach is directed to a visual object. Thus PRR is a candidate area for reading out a patient's intended reach goals for neural prosthetic applications. For natural behaviors, reach goals are not always based on the location of a visual object, e.g., playing the piano following sheet music or moving following verbal directions. So far it has not been directly tested whether and how PRR represents reach goals in such cognitive, nonlocational conditions, and knowing the encoding properties in various task conditions would help in designing a reach goal decoder for prosthetic applications. To address this issue, we examined the macaque PRR under two reach conditions: reach goal determined by the stimulus location (direct) or shape (symbolic). For the same goal, the spiking activity near reach onset was indistinguishable between the two tasks, and thus a reach goal decoder trained with spiking activity in one task performed perfectly in the other. In contrast, the LFP activity at 20–40 Hz showed small but significantly enhanced reach goal tuning in the symbolic task, but its spatial preference remained the same. Consequently, a decoder trained with LFP activity performed worse in the other task than in the same task. These results suggest that LFP decoders in PRR should take into account the task context (e.g., locational vs. nonlocational) to be accurate, while spike decoders can robustly provide reach goal information regardless of the task context in various prosthetic applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1152/jn.00063.2011DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3289477/PubMed CentralArticle
ORCID:
AuthorORCID
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2012 American Physiological Society. Submitted 24 January 2011; Accepted 8 November 2011. First published November 9, 2011. We thank Drs. Markus Hauschild, Igor Kagan, Melanie Wilke, Michael Campos, and Bardia Behabadi for scientific discussion, Tessa Yao for editorial assistance, Kelsie Pejsa and Nicole Simmons for animal care, and Viktor Shcherbatyuk for technical assistance. This work was supported by National Institutes of Health (NIH) Grant EY-013337. E. J. Hwang was supported by NIH Research Service Award T32 NS-007251 and Career Development Award K99 NS-062894.
Funders:
Funding AgencyGrant Number
NIHEY-013337
NIH Predoctoral FellowshipT32 NS-007251
NIHK99 NS-062894
Subject Keywords:sensory-motor; visuomotor and motor neurons; parietal cortex; symbolic reach; direct reach; neural prosthetics
Issue or Number:3
PubMed Central ID:PMC3289477
DOI:10.1152/jn.00063.2011
Record Number:CaltechAUTHORS:20120214-111532983
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120214-111532983
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29279
Collection:CaltechAUTHORS
Deposited By:INVALID USER
Deposited On:15 Feb 2012 19:20
Last Modified:09 Nov 2021 17:05

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