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Asymmetric patterns of gap junctional communication in developing chicken skin

Serras, Florenci and Fraser, Scott and Chuong, Cheng-Ming (1993) Asymmetric patterns of gap junctional communication in developing chicken skin. Development, 119 (1). pp. 85-96. ISSN 0950-1991.

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To study the pattern of gap junctional communication in chicken skin and feather development, we injected Lucifer Yellow into single cells and monitored the transfer of the fluorescent dye through gap junctions. Dye coupling is present between cells of the epithelium as well as between cells of the mesoderm. However, dye transfer did not occur equally in all directions and showed several consistent patterns and asymmetries, including: (1) no dye coupling between mesoderm and epithelium, (2) partial restriction of dye coupling at the feather bud/interbud boundary during early feather bud development, (3) preferential distribution of Lucifer Yellow along the anteroposterior axis of the feather placode and (4) absence of dye coupling in some epithelial cells. These results suggest the presence of preferential pathways of communication that may play a role in the patterning of chicken skin.

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Additional Information:© 1993 The Company of Biologists Limited. Accepted 11 June 1993. We thank Jean Paul Revel, Andrés Collazo and John Shih for their critical comments on the manuscript. This work was supported by a grant of the Netherlands Organization for Scientific Research (NWO) to F. S. and grants from NIH and NSF to C.-M. C.
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Netherlands Organization for Scientific Research (NWO)UNSPECIFIED
Subject Keywords:gap junction, intercellular communication, dye coupling, skin appendages, pattern formation, feather development
Record Number:CaltechAUTHORS:20120301-095740121
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29545
Deposited By: Tony Diaz
Deposited On:20 Mar 2012 22:36
Last Modified:26 Dec 2012 14:54

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