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The Immunoglobulin Heavy Chain Locus Contains Another B-Cell-Specific 3' Enhancer Close to the α Constant Region

Matthias, Patrick and Baltimore, David (1993) The Immunoglobulin Heavy Chain Locus Contains Another B-Cell-Specific 3' Enhancer Close to the α Constant Region. Molecular and Cellular Biology, 13 (3). pp. 1547-1553. ISSN 0270-7306. PMCID PMC359466.

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The transcription of immunoglobulin genes is controlled by variable region promoters and by enhancers, both of which are lymphoid specific. Because immunoglobulin genes are subject to an extremely complex regulation, we anticipated that there might be additional control elements for these genes. We therefore sought additional enhancers and demonstrate here that there is indeed another weak transcriptional enhancer just 3' to the mouse alpha constant region. This novel immunoglobulin enhancer is lymphoid specific and at two positions can bind members of the Oct family of transcription factors.

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URLURL TypeDescription​MCB.13.3.1547DOIArticle CentralArticle
Baltimore, David0000-0001-8723-8190
Additional Information:© 1993 American Society for Microbiology. Received 30 November 1992. Accepted 9 December 1992. We thank K. Calame (New York) for providing phage Ch3'Cα 12A, the Japanese Cancer Research Resources Bank for phages Ch.M.Ig ε-12 and Ch.M.Ig γ2b-2, J. Stavnezer (Worcester) for cell lines 22D and BFO-3, Astar Winoto for discussions, and R. Clerc for critical reading of the manuscript. During the largest part of this work P.M. was the recipient of a fellowship from the Swiss National Science Foundation; this work was also supported by NIH grant GM39458 to D.B.
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Swiss National Science Foundation (SNSF)UNSPECIFIED
PubMed Central ID:PMC359466
Record Number:CaltechAUTHORS:20120308-110427034
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Official Citation:The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region. P Matthias and D Baltimore Mol. Cell. Biol. March 1993 13:1547-1553; doi:10.1128/MCB.13.3.1547
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29647
Deposited By: Ruth Sustaita
Deposited On:12 Mar 2012 16:00
Last Modified:06 Nov 2017 23:04

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