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Pathway Analysis of Protein Electron-Transfer Reactions

Onuchic, José Nelson and Beratan, David N. and Winkler, Jay R. and Gray, Harry B. (1992) Pathway Analysis of Protein Electron-Transfer Reactions. Annual Review of Biophysics and Biomolecular Structure, 21 . pp. 349-377. ISSN 1056-8700. doi:10.1146/annurev.biophys.21.1.349.

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One of the central challenges in molecular biophysics is to understand how proteins control biochemical reactions in living organisms. In their folded states, proteins exhibit a variety of structural fluctuations. The question before us is; how do protein structure and dynamics control biological function? Our goal is to develop tools that allow us to simulate and understand those aspects of biomolecular structure and dynamics that establish the unique capabilities of these molecules. Our hope is to arrive at a deeper understanding of the mechanisms that control biochemical reactions and to establish design criteria for new proteins that will perform specific tasks.

Item Type:Article
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URLURL TypeDescription DOIArticle
Winkler, Jay R.0000-0002-4453-9716
Gray, Harry B.0000-0002-7937-7876
Additional Information:© 1992 Annual Reviews. Work in San Diego was funded by the National Science Foundation (Grant No. DMB-9018768) and a research contract from the Jet Propulsion Laboratory, supported by the Department of Energy’s Catalysis/Biocatalysis Program. This work was performed in part at the Jet Propulsion Laboratory, California Institute of Technology, and was sponsored by the Department of Energy’s Catalysis/Biocatalysis Program (Advanced Industrial Concepts Division), through an agreement with the National Aeronautics and Space Administration. Experimental work at the Beckman Institute was supported by the National Science Foundation and the National Institutes of Health.
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Department of Energy (DOE)UNSPECIFIED
Record Number:CaltechAUTHORS:20120322-085550897
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29805
Deposited By: Tony Diaz
Deposited On:17 Apr 2012 22:27
Last Modified:09 Nov 2021 19:30

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