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Allatostatin-A neurons inhibit feeding behavior in adult Drosophila

Hergarden, Anne Christina and Tayler, Timothy D. and Anderson, David J. (2012) Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 109 (10). pp. 3967-3972. ISSN 0027-8424. PMCID PMC3309792. doi:10.1073/pnas.1200778109.

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How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood. Studies in Drosophila larvae have yielded information about neuropeptides and circuits that promote feeding, but a peptidergic neuron subset whose activation inhibits feeding in adult flies, without promoting metabolic changes that mimic the state of satiety, has not been identified. Using genetically based manipulations of neuronal activity, we show that activation of neurons (or neuroendocrine cells) expressing the neuropeptide allatostatin A (AstA) inhibits or limits several starvation-induced changes in feeding behavior in adult Drosophila, including increased food intake and enhanced behavioral responsiveness to sugar. Importantly, these effects on feeding behavior are observed in the absence of any measurable effects on metabolism or energy reserves, suggesting that AstA neuron activation is likely a consequence, not a cause, of metabolic changes that induce the state of satiety. These data suggest that activation of AstA-expressing neurons promotes food aversion and/or exerts an inhibitory influence on the motivation to feed and implicate these neurons and their associated circuitry in the mechanisms that translate the state of satiety into alterations in feeding behavior.

Item Type:Article
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Anderson, David J.0000-0001-6175-3872
Additional Information:© 2012 by the National Academy of Sciences. Freely available online through the PNAS open access option. Contributed by David J. Anderson, January 17, 2012 (sent for review October 20, 2011). We thank L. Wang and H. Inagaki for helpful comments on the manuscript, G. Carvalho and W. W. Ja for advice on the CAFE assay, B. Al-Anzi and members of the Anderson laboratory for helpful discussions. T.D.T. was supported by a Caltech Biology Divisional Fellowship, a National Institutes of Health Postdoctoral Training Grant (NS007251), and an individual National Research Service Award Fellowship (5F32NS058132). A.C.H. was supported by a Howard Hughes Medical Institute (HHMI) Predoctoral Fellowship and by National Science Foundation Frontiers in Integrative Biological Research Grant EF-0623527 (M. J. Dickinson, principal investigator). D.J.A. is an investigator of the HHMI. Author contributions: A.C.H. and D.J.A. designed research; A.C.H. performed research; A.C.H. and T.D.T. contributed new reagents/analytic tools; A.C.H. and D.J.A. analyzed data; and A.C.H. and D.J.A. wrote the paper. The authors declare no conflict of interest.
Funding AgencyGrant Number
Caltech Biology Divisional FellowshipUNSPECIFIED
NIH Postdoctoral FellowshipNS007251
NIH Postdoctoral Fellowship5F32NS058132
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:10
PubMed Central ID:PMC3309792
Record Number:CaltechAUTHORS:20120327-134518305
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Official Citation: Anne Christina Hergarden, Timothy D. Tayler, and David J. Anderson Allatostatin-A neurons inhibit feeding behavior in adult Drosophila PNAS 2012 109 (10) 3967-3972; published ahead of print February 15, 2012, doi:10.1073/pnas.1200778109
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29860
Deposited By: Ruth Sustaita
Deposited On:27 Mar 2012 21:03
Last Modified:09 Nov 2021 19:31

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