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Signal Transduction Pathways Involving Protein Phosphorylation in Prokaryotes

Bourret, Robert B. and Borkovich, Katherine A. and Simon, Melvin I. (1991) Signal Transduction Pathways Involving Protein Phosphorylation in Prokaryotes. Annual Review of Biochemistry, 60 . pp. 401-441. ISSN 0066-4154. doi:10.1146/annurev.biochem.60.1.401.

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Bacteria are capable of sensing a wide variety of environmental signals, including changes in chemical concentrations, the presence of a host organism, or variation in physical parameters such as temperature, osmolarity, viscosity, or light. One response to changing conditions is to move to a more "favorable" locale; changes in locomotive behavior can be observed less than one second after a change in chemical composition of the medium. Another possible course of action is to adapt the cell to the new environment, either by changing enzyme activity or by altering expression of specific genes or groups of genes. The bacterium may use the modified enzymes or new gene products to adjust to its surroundings temporarily, or to establish a new long-term state (e.g. the sporulation response to starvation).

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Additional Information:© 1992 Annual Reviews. We thank R. L. Bennett, H. C. Berg, F. W. Dahlquist, F. E. Dailey, J. J. Falke, J. A. Gegner, G. L. Hazelbauer, D. E. Koshland Jr., S. Kustu, J. Liu, P. Matsumura, D. F. McNally, A. J. Ninfa, J. S. Parkinson, D. A. Sanders, T. J. Silhavy, R. C. Stewart, K. Volz, R. M. Weis, A. J. Wolfe, R. Yaghmai, and P. Youngman for communication of unpublished results and/or helpful discussions; and L. Alex, A. Glasgow, and C. O’Day for comments on the manuscript. This work was supported by National Research Service Award Fellowships AI07798 (to R.B.B.) and GM11223 (to K.A.B.) Grant AI19296 from the National Institutes of Health (to M.I.S.).
Funding AgencyGrant Number
National Research Service Award FellowshipsAI07798
National Research Service Award FellowshipsGM11223
Subject Keywords:two-component regulatory systems, bacterial chemotaxis, regulation of gene expression, phosphohistidine, phosphoaspartate
Record Number:CaltechAUTHORS:20120329-105316879
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29901
Deposited By: Tony Diaz
Deposited On:17 Apr 2012 20:56
Last Modified:09 Nov 2021 19:32

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