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Applications of high-throughput sequencing to symbiotic nematodes of the genus Heterorhabditis

Schwartz, Hillel T. and Antoshechkin, Igor and Sternberg, Paul W. (2011) Applications of high-throughput sequencing to symbiotic nematodes of the genus Heterorhabditis. Symbiosis, 55 (3). pp. 111-118. ISSN 0334-5114.

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Entomopathogenic nematodes of the genus Heterorhabditis live in symbiosis with pathogenic Photorhabdus bacteria. Heterorhabditis nematodes are entirely dependent on these bacteria for their food source; in return, the nematodes offer the bacteria a way to infect and kill insects. For their part, Photorhabdus bacteria are lethal to a broad range of insect hosts, to other nematodes, and to other microorganisms, but not to their Heterorhabditis hosts. These nematodes offer the potential to provide a robust experimental system for the in•depth study of a mutually beneficial symbiotic relationship, with both members of the partnership accessible to molecular and genetic studies. New genomic technologies offer the possibility for this potential to be realized, and for Heterorhabditis nematodes to become a standard model system for the investigation of host•symbiote relationships. We present a perspective on the application of these technologies to nematode•bacterial symbiosis and an update on our efforts to sequence three Heterorhabditis species reported at the recent NemaSym meeting.

Item Type:Article
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URLURL TypeDescription ReadCube access
Schwartz, Hillel T.0000-0002-3448-8652
Antoshechkin, Igor0000-0002-9934-3040
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2012 Springer Science+Business Media B.V. Received: 8 October 2011; Accepted: 4 January 2012; Published online: 18 January 2012.
Issue or Number:3
Record Number:CaltechAUTHORS:20120402-082627418
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:29926
Deposited By: Tony Diaz
Deposited On:11 Apr 2012 21:08
Last Modified:29 Oct 2019 20:50

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