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Subpixel resolving optofluidic microscope based on super resolution algorithm

Zheng, Guoan and Lee, Seung Ah and Yang, Samuel and Yang, Changhuei (2011) Subpixel resolving optofluidic microscope based on super resolution algorithm. In: 2011 IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro. IEEE , Piscataway, NJ, pp. 1362-1365. ISBN 978-1-4244-4127-3.

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We report the implementation of a fully on-chip, lensless, sub-pixel resolving optofluidic microscope (SROFM) based on the super resolution algorithm. The device utilizes microfluidic flow to deliver specimens directly across a complementary metal oxide semiconductor (CMOS) sensor to generate a sequence of low-resolution (LR) projection images, where resolution is limited by the sensor's pixel size. This image sequence is then processed with a pixel super-resolution algorithm to reconstruct a single high resolution (HR) image, where features beyond the Nyquist rate of the LR images are resolved. We demonstrate the device's capabilities by imaging red blood cell, microspheres, protist Euglena gracilis, and Entamoeba invadens cysts with sub-cellular resolution. We also demonstrate the capability of SROFM for malaria infected red blood cell diagnostics.

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Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2011 IEEE. Date of Current Version: 09 June 2011.
Subject Keywords:Super resolution algorithm, optofluidic, microscopy imaging, lab on a chip
Record Number:CaltechAUTHORS:20120416-084201133
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Official Citation:Guoan Zheng; Seung Ah Lee; Yang, S.; Changhuei Yang; , "Subpixel resolving optofluidic microscope based on super resolution algorithm," Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on , vol., no., pp.1362-1365, March 30 2011-April 2 2011 doi: 10.1109/ISBI.2011.5872653 URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30093
Deposited By: Ruth Sustaita
Deposited On:16 Apr 2012 16:06
Last Modified:09 Mar 2020 13:19

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