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Human Serum Protein Adsorption onto Synthesis Nano-Hydroxyapatite

Mohsen-Nia, M. and Bidgoli, M. Massah and Behrashi, M. and Mohsen Nia, A. (2012) Human Serum Protein Adsorption onto Synthesis Nano-Hydroxyapatite. Protein Journal, 31 (2). pp. 150-157. ISSN 1572-3887. doi:10.1007/s10930-011-9384-3. https://resolver.caltech.edu/CaltechAUTHORS:20120416-134004271

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Abstract

Adsorption of human serum proteins (Albumin and total protein) onto high purity synthesis nano-hydroxyapatite (HA), Ca_(10)(PO_4)_6(OH)_2, has been studied in a wide temperature range by UV–visible spectrophotometer. Adsorption isotherm is basically important to describe how solutes interactwith adsorbent, and is critical in optimizing the use of adsorbent. In the present study, the experimental results were fitted to the Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (DR) models to obtain the characteristic parameters of each model and square of the correlation coefficients (R^2). According to the results, the DR isotherm model had the best agreement with the experimental data. The effect of temperature on adsorption of human serum proteins (HSP) onto the synthesized nano-HA was studied. The experimental results indicated that temperature increase generally causes an increase in the adsorption of HSP onto the nano-HA. This is basically due to the effect of temperature on the HSP activity and its diffusion rate on HA surfaces.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s10930-011-9384-3DOIUNSPECIFIED
http://www.springerlink.com/content/b926231qnl8388pg/PublisherUNSPECIFIED
Additional Information:© 2012 Springer Science+Business Media, LLC. Published online: 30 December 2011.
Subject Keywords:Adsorption isotherm; Albumin; Human serum protein; UV–Visible; Nano-hydroxyapatite
Issue or Number:2
DOI:10.1007/s10930-011-9384-3
Record Number:CaltechAUTHORS:20120416-134004271
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20120416-134004271
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30107
Collection:CaltechAUTHORS
Deposited By: Jason Perez
Deposited On:16 Apr 2012 21:43
Last Modified:09 Nov 2021 19:36

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