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Macromere cell fates during sea urchin development

Cameron, R. Andrew and Fraser, Scott E. and Britten, Roy J. and Davidson, Eric H. (1991) Macromere cell fates during sea urchin development. Development, 113 (4). pp. 1085-1091. ISSN 0950-1991.

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This paper examines the cell lineage relationships and cell fates in embryos of the sea urchin Strongylocentrotus purpuratus leading to the various cell types derived from the definitive vegetal plate territory or the veg_2 tier of cells. These cell types are gut, pigment cells, basal cells and coelomic pouches. They are cell types that constitute embryonic structures through cellular migration or rearrangement unlike the relatively non-motile ectoderm cell types. For this analysis, we use previous knowledge of lineage to assign macromeres to one of four types: VOM, the oral macromere; VAM, the aboral macromere, right and left VLM, the lateral macromeres. Each of the four macromeres contributes progeny to all of the cell types that descend from the definitive vegetal plate. Thus in the gut each macromere contributes to the esophagus, stomach and intestine, and the stripe of labeled cells descendant from a macromere reflects the re-arrangement of cells that occurs during archenteron elongation. Pigment cell contributions exhibit no consistent pattern among the four macromeres, and are haphazardly distributed throughout the ectoderm. Gut and pigment cell contributions are thus radially symmetrical. In contrast, the VOM blastomere contributes to both of the coelomic pouches while the other three macromeres contribute to only one or the other pouch. The total of the macromere contribution amounts to 60% of the cells constituting the coelomic pouches.

Item Type:Article
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URLURL TypeDescription
Cameron, R. Andrew0000-0003-3947-6041
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1991 The Company of Biologists Limited. Accepted 28 August 1991. This research was supported by NSF grant DCB-8911829 to R.A.C., by NIH grant HD-25138 to S.E.F., and by NIH grant HD-05753 to E.H.D.
Funding AgencyGrant Number
Subject Keywords:cell lineage, embryo, vegetal plate, Strongylocentrotus purpuratus, macromere
Issue or Number:4
Record Number:CaltechAUTHORS:20120417-132121074
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30138
Deposited By: Tony Diaz
Deposited On:17 Apr 2012 20:33
Last Modified:03 Oct 2019 03:47

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