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Gα12 and Gα13 subunits define a fourth class of G protein α subunits

Strathmann, Michael P. and Simon, Melvin I. (1991) Gα12 and Gα13 subunits define a fourth class of G protein α subunits. Proceedings of the National Academy of Sciences of the United States of America, 88 (13). pp. 5582-5586. ISSN 0027-8424. PMCID PMC51921. doi:10.1073/pnas.88.13.5582.

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Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of genes that encode the α subunits. Amino acid sequence comparisons show that the different alpha subunits fall into at least three classes. These classes have been conserved in animals separated by considerable evolutionary distances; they are present in mammals, Drosophila, and nematodes. We have now obtained cDNA clones encoding two murine alpha subunits, Gα12 and Gα13, that define a fourth class. The translation products are predicted to have molecular masses of 44 kDa and to be insensitive to ADP-ribosylation by pertussis toxin. They share 67% amino acid sequence identity with each other and less than 45% identity with other α subunits. Their transcripts can be detected in every tissue examined, although the relative levels of the Gα13 message appear somewhat variable.

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Additional Information:© 1991 National Academy of Sciences. Contributed by Melvin I. Simon, March 8, 1991. We are grateful to Carol Lee for sequencing assistance, Joyce Ito for help in preparing the manuscript, and Bruce Hamilton, David Horowitz, Michael Lochrie, and Tom Wilkie for many discussions. This work was supported by National Institutes of Health Grant GM34236. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
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Issue or Number:13
PubMed Central ID:PMC51921
Record Number:CaltechAUTHORS:20120418-134954014
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:30173
Deposited On:18 Apr 2012 22:00
Last Modified:09 Nov 2021 19:38

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